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Nolvadex (Tamoxifen)
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Jun
29
Effexor Interactions with other Drugs
June 29, 2011 | Leave a Comment
Effexor Interactions with other Drugs.
Your doctor or pharmacist may already be aware of any possible interactions of Effexor. Do not start, stop or change the dosage of any medicine only after consulting your doctor. In conjunction with such drugs as: MAO inhibitors (eg, furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine), weight-loss drugs (eg, phentermine, sibutramine), tryptophan, taken with Effexor only 2 weeks before treatment and at least 7 days after the last dose of effexor. If you are currently using any of these medications, tell your doctor or pharmacist before starting Effexor, because this can lead to very serious (even fatal) interactions Effexor. Some medications that can affect the heart rhythm (QTc prolongation in the EKG) include amiodarone, dofetilid, pimozide, quinidine, sotalol, procainamide, thioridazine, and erythromycin, among others, may also be combined with this medication adverse effects. Effexor can increase the risk of such influence. QTc prolongation can rarely cause serious (rarely fatal) irregular heartbeat. Consult your doctor or pharmacist for more details informiatsii and instructions on how you can reduce the risk of such influence. Tell your doctor about all medications you are taking, especially: drugs affecting liver enzymes that remove the Effexor out of your body (eg, cimetidine, azole antifungals such as ketoconazole, itraconazole), medicines (eg, antipsychotics such as clozapine / haloperidol, HIV medications such as indinavir, tricyclic antidepressants-TCAs such as desipramine), “water pills” (diuretics such as furosemide), drugs that can cause bleeding / bruising (eg, aspirin, antiplatelet drugs such as clopidogrel, NSAIDs such as ibuprofen, “blood thinners” such as heparin / warfarin). Aspirin may increase the risk of bleeding when using this drug. If your doctor has you take poropisal low-dose aspirin for heart attack or stroke and for prevention (usually at dosages of 81-325 milligrams per day), you should continue taking it unless your doctor instructs you to. Discuss the risks and benefits with your doctor. Also tell your doctor if you are taking any other drugs that increase serotonin, such as lithium, meperidine, propoxyphene, buspirone, dextromethorphan, SSRIs, other SNRIs, St. John’s wort, drugs used to treat migraines such as ” triptans “and dihydroergotamine, drugs such as MDMA /” ecstasy, “amphetamine. Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (eg, diphenhydramine), anti-drugs (eg, carbamazepine), medicine for sleep or anxiety (eg, diazepam, alprazolam, zolpidem), muscle relaxants, narcotic pain relievers from (eg, codeine), psychiatric medicines (eg, chlorpromazine, risperidone, amitriptyline, trazodone). Look at the instructions of all your medicines to see whether they contain ingredients that cause drowsiness. Ask your pharmacist about using those products in safe mode. Cimetidine is a drug, nonprescription drug, which is commonly used to treat indigestion. This may cause undesirable interactions when taking Effexor, ask your pharmacist about other products to treat stomach acid. Buy Effexor on line without rx but do consult your doctor prior to making an internet pharmacy order.
Note:
Effexor is not used with other analogs of this drug. Psychiatric / medical checkups and lab tests (eg, blood pressure, cholesterol levels, control of growth in children) should be performed periodically to monitor your progress or check for side effects. Ask your doctor for more information.
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Clopidogrel 75 mg
June 1, 2011 | Leave a Comment
Clopidogrel (generic Plavix)
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Pharmacological Effects:
Clopidogrel - antiplatelet drugs. Effect of the drug is due to the ability of clopidogrel selectively inhibit the binding of adenosine receptors of platelets, thus inhibited the activation of a complex glycoprotein IIb / IIIa and decreases platelet aggregation. Clopidogrel increases the bleeding time. Antiplatelet action of clopidogrel is dose dependent, with use of the drug at the recommended therapeutic doses, the maximum therapeutic effect occurs within 3-7 days. Clopidogrel irreversibly blocks ADP receptors of platelets, so that they lose their ability to aggregate, the restoration of normal function was restored 7 days after drug withdrawal, as we update platelets.
After oral administration the drug is rapidly absorbed from the gastrointestinal tract. Bioavailability is about 50% and is independent of food intake. Clopidogrel - prodrug, is metabolized in the liver with the formation of the active substance - thiol metabolite of clopidogrel. The main metabolite is a carboxylic acid derivative, which determine the pharmacokinetic profile. Peak drug concentrations in plasma observed after 60 minutes after oral administration. Excreted in the urine and feces as metabolites. The half-life of about 8 hours.
Indications:
Clopidogrel is administered as a prophylactic agent in patients suffering from diseases of the cardiovascular system, in particular for the prevention of atherothrombotic events in patients with myocardial infarction, ischemic stroke and patients with peripheral artery disease.
Clopidogrel is also used in combination with acetylsalicylic acid for the treatment of acute coronary syndrome without ST segment elevation ST (in particular, patients with unstable angina or myocardial infarction without wave Q).
Clopidogrel is used in treatment of patients with acute myocardial infarction-segment elevation ST, when the patient shows thrombolytic therapy.
How to use:
Clopidogrel is taken orally. A tablet recommended to swallow whole, without chewing or crushing, drinking plenty of water. Clopidogrel does not depend on food intake. The duration of treatment and dose usually determines the physician for each patient individually.
Adult and elderly patients for the prevention of atherothrombotic events is usually prescribed for 75mg of the drug (1 tablet), 1 per day. Receiving the drug for prevention after myocardial infarction should be started a few days later, but no later than 35 days later, after suffering an ischemic stroke - after 1 week but no later than 6 months.
Patients with acute coronary syndrome without ST-segment elevation is usually prescribed 300mg once the drug (4 tablets) at the beginning of treatment, then transferred to taking 75mg of the drug 1 per day in combination with acetylsalicylic acid. Dose of acetylsalicylic acid determines the physician individually, usually it is 75-325mg per day, however, due to the increased risk of bleeding did not exceed the recommended daily dose of aspirin 100mg. Maximum therapeutic effect observed after 3 months of therapy.
In acute myocardial infarction is usually prescribed 300mg of the drug once at the beginning of treatment, then switching to the use of a drug 75mg once daily in combination with acetylsalicylic acid. When treating patients over the age of 75 years, the drug starts with 75mg of the drug 1 time per day, skipping the loading dose of the drug at the beginning of therapy. Duration of treatment for at least 4 weeks.
Data on the need for dose adjustment of the drug in patients with impaired liver function and / or kidney disease, are absent.
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Side effects:
Using the drug clopidogrel in patients noted the development of such adverse reactions:
From the blood system: thrombocytopenia, granulocytopenia, neutropenia, anemia (including aplastic anemia), in a few cases noted the development of thrombotic thrombocytopenic purpura syndrome (Moshkovitsa) and Henoch-Schonlein purpura. In addition, frequently noted the development of different localization of bleeding in patients receiving the drug clopidogrel, including gastrointestinal and nasal bleeding, as well as ocular and intracranial hemorrhage
From the gastrointestinal tract and liver: stomatitis, nausea, vomiting, indigestion, pain in the epigastric region, violations of the chair, gastritis and peptic ulcers of the stomach and duodenum. In addition, the possible elevation of liver enzymes and increased levels of bilirubin in the blood.
Allergic reactions: skin rash, itching, rash, maculopapular rash, bronchospasm, angioedema.
Other: cough, arrhythmia, pulmonary embolism, fatigue, confusion, headache, fever, myalgia, arthralgia, hematuria.
With the development of side effects should stop taking the drug and call your doctor.
In the case of bleeding, including hidden, you should contact your doctor, since the drug prolongs bleeding time and increases the risk of complications from bleeding. If the observed development of abnormal bleeding, including bleeding gums, it is necessary to conduct a study of the hemostatic system, in addition, when using the drug clopidogrel is recommended to regularly monitor liver function.
Patients taking the drug clopidogrel, should inform health care workers (including dentists) of the medication.
Contraindications:
Individual hypersensitivity to the drug.
Severe liver damage, jaundice, accompanied by cholestasis.
Due to the fact that the drug contains lactose, it is not prescribed to patients with glucose-galactose malabsorption and hereditary lactase deficiency.
Clopidogrel is not used for the treatment of patients with active bleeding, including bleeding from the peptide ulcer or intracranial hemorrhage.
Clopidogrel is contraindicated during pregnancy and breastfeeding.
In connection with unproven efficacy and safety of the drug in patients under 18 years of clopidogrel should not be used in pediatrics.
Clopidogrel should be prescribed with care to patients with an increased risk of bleeding due to trauma, surgical interventions, as well as violations of the blood system.
Clopidogrel should be used with caution in patients suffering from impaired renal function and / or liver.
Do not take the drug for 7 days before the scheduled surgery.
Pregnancy:
Clopidogrel is contraindicated in pregnancy due to the fact that the safety of the drug to the fetus is not proven.
If necessary, use during lactation should solve the issue of a possible interruption of breastfeeding.
Interaction with other drugs:
The combined use of medication with acetylsalicylic acid indicated a mutual enhancement of their effect on platelet aggregation. Safety of combined treatment with these drugs for more than 12 months is not proven.
Clopidogrel should be used with caution in conjunction with heparin, but the drug clopidogrel to patients receiving heparin therapy, does not require dosage adjustment of the latter.
In the appointment of the drug to patients receiving other thrombolytic drugs, caution should be exercised.
With the simultaneous application of clopidogrel with warfarin may increase the risk of bleeding. Should not be prescribed clopidogrel for patients receiving warfarin therapy.
Clopidogrel should be prescribed with care with medications that have a high degree of association with plasma proteins.
With the simultaneous appointment of a drug with non-steroidal anti-inflammatory drugs with caution.
With the simultaneous application of the drug with antacid drugs are not observed changes in pharmacokinetic parameters of clopidogrel.
Caution must be exercised in the appointment of the drug clopidogrel patients taking inhibitors of glycoprotein IIb / IIIa.
Overdose:
In the application of excessive doses of the drug in patients there is an increase in bleeding time.
No specific antidote. In case of overdose symptomatic treatment is shown. In the case require immediate correction of the state, shows platelet transfusion.
Product:
Film-coated tablets, 10 pieces per blister, 1 or 2 blisters per carton.
Storage Conditions:
Clopidogrel is recommended that you store in a dry place away from direct sunlight at a temperature above 25 degrees Celsius.
Shelf life - 3 years.
Synonyms:
Plavix, Zilt, Agregal, Listab.
Ingredients:
1 tablet, film coated contains:
Clopidogrel bisulfate (recalculated as clopidogrel) - 75mg;
Excipients, including lactose.
Attention!
Before using the drug Clopidogrel you should consult your doctor. These operating instructions refer to a free transfer and is intended solely for information. For more information, please contact the manufacturer annotations. Buy Clopidogrel online without a prescription (no rx needed), but consult your doctor before purchasing the drug.
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Generic Drugs: Is There a Difference Between Generic Drugs and Brand?
May 30, 2011 | Leave a Comment
Before patients buy generic drugs online they want to know the answers to some of their questions, regarding generics. Why can one buy generic drugs cheap? Are generic drugs effective? Where can I buy generic drugs without a prescription cheap?
Today a lot of online pharmacies offer cheap generic drugs without a prescription and thousands of patients around the world take the opportunity to save on very expensive brand medications from a local pharmacy store. Generics are full analogues of brand ones, but are available to order online cheaper. Online pharmacies sell some drugs without a prescription which makes generic drugs purchase online even more convenient as you do not have to see a doctor.
Patients of all age groups and walks of life want to be treated effective and quality medicine. But here’s to suit all your medicines in different ways: some prefer to buy expensive original drugs, while others believe that lower-cost counterparts in no way inferior to well-known brands. In short, demand is there for any kind of drugs, as ill and eating a man does not stop never. What to and enjoy all kinds of pharmaceutical companies, letting the world market many drugs under various trade names.
According to recent statistics, the proportion of generic counterparts of drugs (generics) in the markets of many countries will only increase. Although the dynamics of growth is not the same: if the U.S. resorted to the use of generic drugs in approximately 15% of the treatment of diseases in Europe - 40-50%, in the post-Soviet countries - up to 80-90%. But do not be afraid of these numbers. Because generic - a quality product, which according to its pharmacological data of the original copies. The active substance in the analog and the original is absolutely identical. But the price of drugs is much different. And obviously for the benefit of generics. Why is this happening? To do this, to understand the differences in the production of both options medication.
When a pharmaceutical company synthesized a new drug, it is patent the name and performs a full spectrum of possible research - from clinical to experimental. Their progress is determined by: the exact formula, the effectiveness of the drug and all its side effects. At this preliminary stage can take up to 10 years. If we consider that a patent for the drug is given by an average of 20 years (sometimes 25), then for the remaining 10-15 years “exclusive use” producer has to invest heavily in the campaign, so with the help of massive purchases “recapture” the cost of wasted millions to test and make a profit. It is clear that the original price of such drugs will be essential.
What happens after the expiration of a patent? Right to manufacture the same drug, but under a different name may acquire any other company. Since emerging on the market, for example, not nootropil, and piracetam. This medicine is an exact copy of an analog, but since its production has already spent far less money, and it determines the selling price, which is an order of magnitude lower. So the generic - a kind of high-quality tracing paper once a patented drug, but at an affordable cost for a wide range of customers.
Dzhenericheskie drugs all over the world before they go on sale are thoroughly tested for compliance with the equivalence of the original drug. Such a study is conducted in three areas:
Pharmaceuticals - medicines should:
contain the same active ingredients;
introduced an identical manner;
be similar in concentration and its effect on the body.
Biological - the deviation between the analogs and copies are allowed no more than 15-20% of such parameters:
period of drug intake;
time to reach maximum concentration;
type and duration of excretion from the body.
Clinical - generic shall match the original for these indicators:
active substance;
security;
efficiency.
Thus, the generic is a quality drug, which contains the same active ingredient as the original drug, same adjuvants and production technology.
Summarizing the above, conclusions can be drawn: the use of generic drugs is absolutely justified, since it gives the doctor and patient choice; can treat almost all people from different walks of life, available in a price range, efficient and safe. In addition, taking a growing niche market of medicines, generic drugs stimulate the company’s original look promising new directions in drug development.
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Diflucan (Fluconazole) and Other Antifungals
May 24, 2011 | Leave a Comment
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Diflucan (Fluconazole) and Other Azole Antifungals
Type of Drug: Azole Antifungals (Diflucan, Fluconazole)
Brand Names: Diflucan
Generic Ingredient: Fluconazole Diflucan
Generic Ingredient: Itraconazole Sporanox Ketoconazole Extina Nizoral Ketozole Xolegel Posaconazole Noxafil Voriconazole Wend
Prescribed For: Fungal infections of the blood, mouth, throat, vagina, or central nervous system.
Fluconazole, posaconazole, and itraconazole can be used to treat opportunistic fungal infections that inflict many people with HIV or cancer whose immune systems have been compromised.
Generic Fluconazole is called Diflucan and it is an extremely popular and effective drug for yeast infection treatment today. Millions of patients buy Diflucan for yeast infection treatment and more and more people buy generic Diflucan online at a price much cheaper than in a regular pharmacy shop. Diflucan online is available to purchase without a prescription or visiting a doctor. Besides online pharmacy Diflucan cost is up to five time less, so you save serious money buying Diflucan without RX from the comfort of your home without the need to get a prescription or waiting in the line to see your doctor.
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General Information
Azole antifungals are used to treat a variety of fungal organisms, including Candida, aspergillus, cryptococcus, blastomycosis, fusarium, histoplasmosis, and Scedosporium. They work by inhibiting important enzyme systems in the organisms they attack. These drugs are broken down in the liver.
Cautions and Warnings
Do not take azole antifungals if you are allergic or sensitive to any of their ingredients. People who are allergic to similar antifungals may also be allergic to these drugs, but cross-reactions are not common and serious allergic reaction is rare.
Azole antifungals can affect heart rhythm and should be used with caution if you have a history of abnormal heart rhythms.
Rarely, azole antifungals can cause liver damage. The drugs should be used with caution in people with liver disease. At least one in every 10,000 people who take ketOGonazole develop liver inflammation. The inflammation generally subsides when the drug is discontinued.
Voriconazole tablets contain lactose. They should not be taken by patients with rare hereditary problems of galactose intolerance, Lapp-lactase deficiency, or glucose-galactose malabsorption.
Rash may be an important sign of drug toxicity, especially in people with HIV or others with compromised immune function. Report any rashes, especially ones that do not heal readily, to your doctor.
These drugs can have very serious effects if combined with other medicines. See “Drug Interactions” for specific information.
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Possible Side Effects
Side effects are generally more common among people with HIV.
Generic Diflucan Fluconazole (Diflucan 100 mg, 150 mg and 250 mg)
Less common: liver toxicity, as measured by increases in specific lab tests. These changes in lab values are more common in people with HIV or cancer, who are more likely to be taking several drugs.
Rare: seizures and exfoliative skin disorders. People with
HIV or cancer who take fluconazole for fungal infections
may develop severe liver or skin problems. Contact your
doctor if you experience any side effect not listed above.
Itraconazole
• Most common: nausea, vomiting, and rash.
Less common: diarrhea, abdominal pain, appetite loss, swelling in the legs or feet, fatigue, fever, feeling unwell, itching, headache, dizziness, reduced sex drive, tiredness, high blood pressure, liver or kidney function abnormalities, low blood potassium, and impotence.
Rare: gas, sleeplessness, depression, ringing or buzzing in the ears, bronchitis, chest pain, coughing, and swollen or painful breasts in men or women. Contact your doctor if you experience any side effect not listed above.
Usual Dose
Fluconazole (generic Diflucan)
Adult and Child (age 14 and over): Diflucan 100-400 mg once a day. Child: Diflucan 1.3-5.5 mg per lb. of body weight once a day; no more
than 400 mg Diflucan a day.
Overdosage
Overdose is likely to result in exaggerated drug side effects. Doses of posaconazole up to 1600 mg a day have been taken without any adverse reactions. Take the victim to a hospital emergency room. ALWAYS bring the prescription bottle or container.
When taking generic Diflucan fluconazole, regular doctor visits are necessary to monitor liver function and general progress. Call your doctor if you develop severe diarrhea; vomiting; reddening, loosening, blistering, or peeling of the skin; darkening of the urine; jaundice (yellowing of the skin or whites of the eyes); loss of appetite; or abdominal pain, especially on the right side. Report other symptoms that are bothersome or persistent.
Itraconazole must be taken for at least 3 months to determine its effectiveness; otherwise, the infection may return.
If you forget a dose of one of these medicines, take it as soon as you remember. If it is almost time for your next dose, skip the one you forgot and continue with your regular schedule. Do not take a double dose.
Special Populations
Pregnancy/Breast-feeding: Animal studies with Diflucan show effects on the fetus that have not been seen in humans. Pregnant women should not use azole antifungals unless the possible benefits outweigh the risks.
These drugs pass into breast milk. Nursing mothers who must these drugs should use infant formula.
Seniors: Seniors may require a reduced dosage of fluconazole due to age-related loss of kidney function. No dosage adjustments are necessary with other azole antifungals.
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Proscar (Finasteride)
May 18, 2011 | Leave a Comment
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CAN CANCER OF THE PROSTATE BE CURED?
May 18, 2011 | Leave a Comment
The quicker it can be diagnosed and treated, the better the chances are for cure. Any cure depends on the treatment, so that’s the next thing your urologist will look. What will work best for this type and size of cancer on this patient considering his general health, his wishes and his age?
Urologists classify cancers in four stages, A, B, C, and D.
STAGE A:
In stage A cancer it is silent, the patient doesn’t know he has it. It can’t be felt by digital rectal examination or even suspected for any reason. A PSA test here might show up the elevated antigen and lead to a suspicion. This is one reason many people are suggesting that PSA tests be given to every man over forty years of age as a part of his annual physical. The stage A of cancer is almost always found when a TURP or other operation is carried out for BPH. The removed prostate tissue examined by a pathologist will show evidences of cancer.
STAGE B:
Stage B cancer is usually detected as a lump or hard or firm area on the prostate’s two outer lobes during a digital rectal examination. This might be after a man has reported BPH symptoms, or during a routine.
STAGE C:
In stage C the cancer is usually found by digital rectal exam or after a BPH caused exam. Here much and sometimes all of the prostate that can be felt is hard and firm indicating the cancer. At this stage the cancer probably has spread from the prostate itself into the immediate vincinity.
STAGE D:
In stage D the cancer has spread from the prostate into any of the adjoining body areas such as the lymph nodes. By this time the cancer may also have spread into the lungs, or bones or any part of the body.
Information:Casodex (Bicalutamide) 50 mg is a well known prescription drug used in the treatment of prostate. You can buy it online without a prescription. No rx Casodex order can be made at a low price from the international online pharmacy.
Tags: bicalutamide, CANCER, casodex, pharmacy, TreatmentAug
1
Cilostazol
August 1, 2009 | Leave a Comment
Generic Name
Cilostazol (sil-oe-STAY-zol) Lq
Brand Name Pletal
Type of Drug Antiplatelet.
Prescribed For Intermittent claudication.
General Information
In intermittent claudication, leg muscles go into spasm due to reduced blood flow. This occurs when plaque buildup narrows blood vessels leading to the calf or other leg muscles. People with this condition often develop leg pain after walking only a short distance. Cilostazol prevents blood platelets from “clumping together” to begin the process of forming a blood clot, which can further obstruct arteries and worsen intermittent claudication. This drug is broken down in the liver.
Cautions and Warnings
Do not take this drug if you are allergic or sensitive to any of its ingredients.
?P,Ople with congestive heart failure (CHF) should not take cilostazol. Some studies indicate that long-term use of this drug may cause cardiovascular problems.
People with hemostatic disorders or active pathologic bleeding should not take cilostazil.
Drug Interactions
• Avoid mixing cilostazol with ketoconazole, itraconazole, fluconazole, miconazole, fluvoxamine, fluoxetine, nefazodone, or sertraline because this interaction may slow the breakdown of cilostazol, prolonging its effects. Cilostazol dosage is reduced by 50% when it is combined with any of these drugs.
• Aspirin can increase the anticoagulant (blood-thinning) effect of cilostazol, but this combination has not caused serious bleeding problems. There is no information on the effect of combining cilostazol and other antiplatelet or anticoagulant drugs. Cilostazol dosage is reduced by 50% when it is combined with any of these drugs.
• Diltiazem increases cilostazol blood levels by about 50%. Cilostazol dosage is reduced by 50% when it is combined with diltiazem.
• Erythromycin and similar antibiotics increase cilostazol blood levels. Take half the regular dose of cilostazol when combining it with any of these drugs.
• Combining cilostazol and omeprazole increases the effects of cilostazol. Cilostazol dosage is reduced by 50% when it is combined with omeprazole.
• Smoking reduces the Olectiveness of cilostazol by causing the liver to break it down faster.
Food Interactions
Take this drug on an empty stomach at least 30 minutes before or 2 hours after meals. Do not drink grapefruit juice at any time while
above. with dosage.
dache, infection, abdominal pain, ab- arrhea.
pitations, rapid heartbeat. dizziness, sea, sore throat, runny nose, back pain, arms or legs.
cough, fainting, and muscle aches. cts can occur in almost any part of the doctor if you experience any side ef- e.
Possible Side Effects
The risk of side effects
♦ Most common: headache
• stool, and diarrhea. • Common: heart palpitations
• stomach, nausea
• swelling in the
♦ Less common: gas,
♦ Rare: Rare side effects body. Contact your fect not listed taking cilostazol because it can interfere with the breakdown of the drug.
Usual Dose
Adult: 100 mg twice a day. 50 mg twice a day when combined with other drugs that may increase the effect of cilostazol. Child: not recommended.
Overdosage
Symptoms of overdose are likely to be the most common side effects. Overdose victims should be taken to a hospital emergency room. ALWAYS bring the prescription bottle or container.
Special Information
Several weeks of cilostazol treatment may be necessary before you notice any improvement in symptoms. Maximum benefit usually occurs after 12 weeks.
If you forget a dose, take it as soon as you remember. If it is almost time for your next dose, skip the forgotten dose and continue with your regular schedule. Do not take a double dose.
Special Populations
Pregnancy/Breast-feeding: Animal studies suggest that cilostazol may harm the fetus, but there is no information on the effect of cilostazol in pregnant women. When this drug is considered crucial by your doctor, its potential benefits must be carefully weighed against its risks.
cilostazol may pass into breast milk. Nursing mothers who must take this drug should use infant formula.
Seniors: Seniors can take this drug without special precaution.
Jul
16
Alpha Blockers
July 16, 2009 | Leave a Comment
Type of Drug
Alpha Blockers
Brand Names
Generic Ingredient. Alfuzosin Uroxatral
Generic Ingredient: Terazosin Hydrochloride Hytrin
Prescribed For
High blood pressure (terazosin) and benign prostatic hyperplasia (BPH) (alfuzosin and terazosin).
General Information
Alpha blockers block nerve endings known as alpha, receptors. They reduce blood pressure by dilating (widening) and reducing pressure within the blood vessels. The maximum blood-pressurelowering effect of terazosin is seen between 2 and 6 hours after taking a single dose. Terazosin’s effect lasts for 24 hours.
In BPH, alpha blockers work by relaxing smooth muscles in the prostate and neck of the bladder. This effect is produced by blockage of alpha, receptors in the affected muscles. Despite the fact that terazosin alleviates the urinary symptoms of BPH, the drug’s long-term effect on complications of BPH or the need for urinary surgery is not known. Alpha blockers are broken down in the liver.
Cautions and Warnings
Do not take alpha blockers if you are allergic or sensitive to any of their ingredients.
Alpha blockers may cause dizziness and fainting, especially after the first few doses. This is known as the “first-dose effect” and may be minimized by limiting the first dose to 1 mg at bedtime. The first-dose effect occurs in about 1 % of people and may recur if the drug is stopped for a few days and then restarted.
Do not take alfuzosin if you have moderate to severe liver disease since this can drastically increase blood concentrations of the drug.
Alpha blockers should be taken with caution if you have kidney disease, since blood concentrations may be increased by 50%.
Do not take these medicines if you are already taking an alphablocker for either high blood pressure or prostate problems.
Terazosin may slightly reduce cholesterol levels and improve the high-density lipoprotein (HDL) to low-density lipoprotein (LDL) ratio, a positive step for people with blood-cholesterol problems.
Terazosin may reduce the counts of red and white blood cells.
People taking terazosin may experience a weight gain of about 2 lbs.
Possible Side Effects
Alfuzosin
✓ Most common: dizziness, fatigue, upper respiratory infection, and headache.
✓ Less common: pain, abdominal pain, upset stomach, constipation, nausea, impotence, bronchitis, sinusitis, sore throat, low blood pressure, dizziness, and fainting.
✓ Rare: rash, rapid heartbeat, chest pain, and painful and persistent erection. Contact your doctor if you experience any side effect not listed above.
Terazosin
✓ Most common: dizziness, weakness, and headache.
✓ Rare: depression, reduced sex drive or abnormal sexual function (including painful and persistent erection), fluid retention, and weight gain. Contact your doctor if you experience any side effect not listed above.
Drug Interactions
• When taken with other blood-pressure-lowering drugs, terazosin severely reduces blood pressure.
• Verapamil may increase blood levels of terazosin.
• Antifungal drugs such as itraconazole and ketoconazole and protease inhibitors interfere with the breakdown of alfuzosin in the liver, raising the amount of drug in the blood.
• Alfuzosin moderately increases the amount of diltiazem in the blood.
• Alpha blockers should not be taken with ritonavir.
Food Interactions
Alfuzosin should be taken with food.
Usual Dose
Alfuzosin: one 10-mg tablet taken after the same meal every day. Do not crush or chew the tablets.
Terazosin: starting dosage-1 mg at bedtime. Dosage may be increased in increments of 1-5 mg to a total of 20 mg a day. Dosages of 10 mg a day are generally needed to control the symptoms of BPH.
Overdosage
Symptoms may include drowsiness, poor reflexes, and very low blood pressure. Take the victim to a hospital emergency room. ALWAYS bring the prescription bottle or container.
Special Information
Take alpha blockers exactly as they are prescribed and do not stop taking it unless directed to do so by your doctor. Avoid over-the-counter drugs that contain stimulants because they may increase your blood pressure.
Alpha blockers may cause dizziness, headache, and drowsiness, especially 2-6 hours after taking your first dose, though these effects may persist after the first few doses. Wait 12-24 hours after taking the first dose before driving, operating machinery, or performing any other task that requires intense concentration. You may take alpha blockers at bedtime to minimize this problem.
Some people undergoing eye surgery who take alpha blockers can experience an unusual effect called “floppy iris syndrome.” Make sure to tell your eye surgeon if you are taking or have ever been treated with an alpha blocker. There is no benefit to stopping alpha-blocker treatment before cataract surgery.
Prostate cancer and BPH may have similar symptoms. Talk to your doctor about ruling out prostate cancer before beginning treatment for BPH.
Call your doctor if you develop severe dizziness, heart palpitations, or any bothersome or persistent side effect.
If you forget a dose, take it as soon as you remember. If it is almost time for your next dose, skip the forgotten dose and continue with your regular schedule. Do not take a double dose.
Special Populations
Pregnancy/Breast-feeding: Alfuzosin is not indicated for use in women. Large dosages of terazosin damage the fetus in animal studies. When alpha blockers are considered crucial by your doctor, their potential benefits must be carefully weighed against their risks.
It is not known if terazosin passes into breast milk. Nursing mothers who must take this drug should use infant formula.
Seniors: Seniors may be more sensitive to the effects of terazosin.
Jul
16
Alitretinoin
July 16, 2009 | Leave a Comment
Generic Name
Alitretinoin (al-ih-TRET-in-oin)
Brand Name
Panretin
Type of Drug Retinoid.
Prescribed For
Skin lesions of Kaposi’s sarcoma (KS).
General Information
Alitretinoin binds to and activates retinoid receptors in human cells. Once activated, these receptors help stimulate the body’s natural mechanisms for limiting tissue growth—in this case, the growth of KS cells. KS lesions, which are primarily associated with human immunodeficiency virus (HIV), can respond to alitretinoin in as little as 2 weeks, but most people do not start to see results for 48 weeks or, in some cases, 14 weeks or more.
Cautions and Warnings
Do not use alitretinoin if you are allergic or sensitive to retinoids or to any of its ingredients.
Alitretinoin is applied to individual KS lesions. It does not treat systemic KS or prevent new KS lesions from forming.
People requiring systemic KS treatment (those who have developed more than 10 new KS lesions within a month) should not use alitretinoin.
People with swollen lymph glands, KS that affects the lungs or other major organ involvement should not use alitretinoin.
Possible Side Effects .
✓ Most common: rash and burning pain at application site.
♦ Common: itchy, flaking, peeling, cracking, oozing, swelling, and inflammation at application site.
Drug Interactions
• Do not use insect repellant products that contain DEET, a widely used chemical repellant. Alitretinoin increases DEET toxicity.
Usual Dose
Adult: Apply 2-4 times a day to KS skin lesions. Seniors should use this drug with caution.
Child: not recommended.
Overdosage
Little is known about the effects of accidental ingestion. Call your local poison control center or a hospital emergency room for information. If you seek treatment, ALWAYS bring the prescription bottle or container.
Special Information
Apply enough alitretinoin gel to cover the entire skin lesion. Allow the gel to dry for 3-5 minutes before covering the area with clothing. Avoid showering, bathing, or swimming for at least 3 hours.
If you use a bandage or dressing, be sure it is not tight and that air can circulate freely over the area.
Avoid applying alitretinoin to unaffected skin because it may be irritated by the drug. Avoid applying near the nose, eyes, or mouth.
Alitretinoin contains alcohol. Always keep it away from any open flame.
Retinoids can cause unusual sensitivity to the sun. While this has not been seen with alitretinoin, you should avoid prolonged exposure to the sun or use sunscreen while taking this drug.
If you forget a dose, apply it as soon as you remember. If it is almost time for your next dose, apply the forgotten dose and then space the rest of your doses throughout the day. Continue with your regular schedule the next day.
Special Populations
PregnancylBreast-feeding., Alitretinoin can harm the fetus when sufficient levels of the drug are present in the mother’s bloodstream, but it is not known if these levels are achieved during routine use of alitretinoin. Women who are or might be pregnant should only use this drug after discussing its potential benefits and risks with their doctors.
It is not known if alitretinoin passes into breast milk. Nursing mothers who must use alitretinoin should use infant formula.
Seniors: There is no information on use of alitretinoin by seniors. Seniors should use it with caution.