Jul
16
Adapalene
July 16, 2009 | Leave a Comment
Generic Name
Adapalene (uh-DAP-uh-lene)
Brand Name Differin
Type of Drug Anti-acne.
Prescribed For Acne.
General Information
Adapalene is similar to a retinoid. Retinoids are compounds related to vitamin A and are used in acne treatment. When adapalene is applied to an acne lesion, it modifies several of the processes involved in skin cell function. It reduces inflammation in the acne lesion and slows the formation of the material that fills the lesion. Very little adapalene is absorbed through the skin.
Cautions and Warnings
Do not use adapalene if you are allergic or sensitive to any of its ingredients. If you are sunburned, wait until your sunburn clears before applying adapalene to your skin. Avoid sun or sunlamp exposure while using adapalene. If you must be in the sun, be sure to apply sunscreen or wear protective clothing over areas where you have applied adapalene. Extreme wind or cold can also be irritating to skin where adapalene has been applied.
Adapalene can irritate the skin if used in combination with products such as medicated or abrasive soaps or cleansers, astringents, or soaps and cosmetics with a strong drying effect. Avoid products containing sulfur, resorcinol, or salicylic acid.
Adapalene can be highly irritating if it gets into your eyes or if it is applied to your lips, the angles of your nose, mucous membranes, cuts, abrasions, or sunburned or damaged skin. Avoid using depilatories or waxing while using adapalene.
Possible Side Effects
V Most common: redness, irritation, dryness, scaling, itching, and burning are common after applying adapalene to your skin. These effects usually occur during the first 24 weeks of adapalene use and subside as treatment continues. Symptoms may be severe enough to cause you to stop using adapalene; call your doctor if this happens to you.
V Rare: skin irritation, stinging sunburn, and worsening acne. Contact your doctor if you experience any side effect not listed above.
Drug Interactions
None known.
Usual Dose
Adult and Child (age 12 and over): Wash affected areas with a mild or soapless cleanser and apply a thin layer of adapalene at bedtime.
Child (under age 12): not recommended.
Overdosage
Chronic ingestion of adapalene can cause liver toxicity and other side effects associated with swallowing large amounts of vitamin A. Swallowing adapalene gel is extremely dangerous for pregnant women, who should not take more vitamin A than is contained in their prenatal vitamins. Infants who swallow adapalene should be taken to a hospital emergency room for treatment.
Special Information
Stop using adapalene and call your doctor if you develop a severe skin reaction or any sign of drug allergy or reaction (symptoms include rash, hives, itching, changes in complexion, and breathing difficulties or irregularities).
Adapalene may exacerbate your acne at first, but you should see improvement within 2 weeks.
If you must be in the sun, be sure to apply sunscreen or wear protective clothing over areas to which you have applied adapalene.
Using more than a thin film of adapalene does not produce better results and may be more irritating to the skin.
If you forget to apply a dose of adapalene, apply it as soon as you remember. If it is almost time for your next application of adapalene, skip the dose you forgot and continue with your regular schedule.
Special Populations
PregnancylBreast-feeding., Animal studies of adapalene have shown no effects on the fetus. Since the effect of adapalene on pregnant women is not known, the drug should be used only when the possible benefits outweigh the risks.
It is not known if adapalene passes into breast milk. Nursing mothers should use infant formula.
Seniors: Seniors may use this drug without special precautions.
Jul
2
Acne: Hormone Treatment
July 2, 2009 | Leave a Comment
Hormone Treatment
Because hormones, especially androgens like testosterone, play a role in acne, changing the balance of these natural compounds in the body can be helpful in some cases. Many young women benefit from taking birth control pills for their acne. This treatment stops the hormone surges and also probably reduces the amount of testosterone that is available to stimulate oil-producing hair follicles and make mischief. Keep in mind, though, that young women who take oral contraceptives for an extended period may have a lowered libido for quite a long time after discontinuing the treatment. 18 (Parents of teenagers may not consider this a negative factor, but it can be very troublesome for a woman in her twenties or thirties.)
Q. You had a question about a teenage girl with acne. Nothing the dermatologist prescribed had worked, and her mother refused to consider birth control pills for her.
My heart goes out to her. I too have suffered with acne my whole life, starting when I was 10 years old. I am now 35.
My parents took me to dermatologists who prescribed pills and creams; we changed my diet; we tried sun exposure and no sun exposure. They kept trying because they knew my self-esteem was suffering. Acne makes you feel ugly.
At the age of 161 saw a gynecologist who suggested birth control pills. I was raised a strict Irish-Catholic, but Mom was open to anything that might help me. Within 2 months of starting birth control pills, my skin was considerably better!
I am one of those people whose body loves the pills. As soon as I stop taking them, my skin starts to break out. I hope my experience will help convince that mother that birth control pills could be the magic she wants for her daughter.
A. When all else fails, birth control pills can be helpful. The hormones counteract testosterone. Yes, young women make this male hormone too. Not every woman tolerates oral contraceptives as well as you do, but doctors frequently prescribe them for hard-to-treat acne.
A dermatologist may also prescribe a very old-fashioned blood pressure drug called spironolactone by itself or in combination with birth control pills. This is an “off label” use of spironolactone, but one with quite a long history. Spironolactone seems to help reduce the action of testosterone or other androgen hormones. That may explain why it is also used to treat women who have excessive facial hair (hirsutism). The dose that dermatologists use for acne is usually one-fourth that used for hirsutism.
Spironolactone is a potassium-preserving diuretic and must not be combined with potassium supplements or other potassium-preserving medications. In addition, spironolactone carries a black-box warning in its. prescribing information that tells doctors in the strongest way possible that this drug causes cancer in animal studies. Generally, therefore, physicians prescribe it only for a limited time. Women are urged not to become pregnant while on this medicine. When it is used in combination with oral contraceptives, that shouldn’t be as much of a concern.
Jul
2
Prescription Pills for Acne
July 2, 2009 | Leave a Comment
Prescription Pills for Acne
When topical antibiotics don’t do the job, dermatologists may prescribe oral medication to get the antibiotic into the bloodstream rather than just on the surface of the skin. Tetracycline and clindamycin have been widely prescribed, but some acne-causing bacteria have developed resistance to them. Now, dermatologists may be more likely to prescribe minocycline. Although this antibiotic works against acne, it is not clear that it is either more effective than other oral antibiotics or less likely to cause undesirable reactions.
Anyone who is prescribed oral antibiotics needs to know This topical treatment has been flying under the radar for years. Some dermatologists tell us that it should have anti-inflammatory action and may be better tolerated than benzoyl peroxide.
Side effects: Redness, dryness, and burning
Downside: Hard to find, although it is available from many online pharmacies. May take several weeks to work. Physicians and pharmacists seem unaware of its effectiveness, and studies are few.
Cost: Approximately $30 for a 30-gram tube
when to take them and whether they should delay taking other treatments, such as supplements or antacids. Patients should discuss all the pros and cons of oral (systemic) antibiotic therapy with the doctor prescribing it. Certain drugs may cause rare but potentially serious side effects, such as the pseudomembranous colitis that is sometimes seen with clindamycin.
One study found that people using antibiotics (oral or topical) to treat their acne were about twice as likely to come down with an upper respiratory tract infection. Colds, flus, and similar upper respiratory tract infections are usually self-limited and rarely a serious threat to health, but it makes sense to evaluate whether the acne is in fact affecting your life so much that you’d be willing to trade it for a cold. It might not make sense to take an antibiotic for mild acne that is not too bothersome.
After completing a course of antibiotic treatment, acne patients may be able to keep their skin clear by using tretinoin gel or a similar product.” Adapalene or tazarotene gel may also be useful.” Using such a topical medicine as follow-up therapy can reduce the amount of antibiotic exposure.
Jul
2
Acne: Prescription Lotions and Gels
July 2, 2009 | Leave a Comment
Prescription Lotions and Gels for Acne Treatment
If treatment with benzoyl peroxide doesn’t get your pimples under control within a couple of months, check with a physician. Dermatologists often prescribe topical antibiotic gels or lotions in addition to or instead of benzoyl peroxide. Erythromycin and clindamycin are old standbys. Because they have been so widely used however, bacteria have begun to develop resistance to them. As a result, dermatologists have been restricting their use and instead turning to other approaches.
One other medication that is being prescribed is azelaic acid (Azelex, Finevin). Like benzoyl peroxide, this topical treatment seems to keep pores from clogging and to discour-age the multiplication and spread of bacteria. It too may result in burning, stinging, redness, or dryness of the skin. In rare instances, dark skin exposed to azelaic acid may develop lighter patches. If you have a cold sore or fever blister that gets worse while you are using an azelaic acid product, notify the prescribing physician immediately.
Tretinoin or a similar compound in the vitamin A family can be very effective in treating acne and reducing the inflammation associated with severe acne. Using topical vitamin A–like compounds (retinoids) early in the course of acne lessens the likelihood of scarring, a complication of the condition. Some doctors prescribe tretinoin together with benzoyl peroxide or with an oral antibiotic such as doxycycline to clear the skin faster. Because it works on the deeper cellular layers of the skin and speeds up cell turnover, it can also
**** Clindamycin Gel (Cleocin T, Clinda-Derm, Evoclin Topical Foam)
Clindamycin is an antibiotic that can be applied to the skin to fight acne-causing bacteria. It may take 2 months to see significant improvement, but generally this treatment is effective. Other topical antibiotics such as erythromycin gel are also effective.
Some prescription products combine an antibiotic with benzoyl peroxide for greater effectiveness. These include BenzaClin and Duac Gel (clindamycin plus benzoyl peroxide) and Benzamycin (erythromycin plus benzoyl peroxide). These are effective but expensive because no generic equivalents are available.
Side effects: Itching, burning, dryness, and peeling. A rare but very serious and dangerous side effect of clindamycin that is extremely unlikely to occur but still possible with the topical form is pseudomembranous colitis. Notify your doctor immediately if you develop persistent or bloody diarrhea.
Downside: Skin bacteria (P. aches) are beginning to develop resistance to topical clindamycin.
Cost: Approximately $50 for a 60-gram tube Tretinoin Gel (Retin-A)
Retin-A speeds up cell turnover and normalizes the lower levels of the skin. With 6 weeks or more of treatment, it is frequently very helpful against acne.
Side effects: Stinging, dryness, redness, flaking, and irritation
Downside: Retin-A makes skin more sensitive to sunburn and sun damage, so stay out of the sun and use effective protection against ultraviolet rays.
Cost: $35 to $50 for 15 grams
bring pimples to the surface more quickly. This means that acne may seem to be getting worse at first rather than better, but with patience the condition should clear up. Tretinoin is also used to smooth out wrinkles due to sun damage.
There is another prescription gel or cream that is based on a vitamin. Nicomide-T gel or cream contains nicotinamide, a form of niacin. Like Retin-A, it is topical but not an antibiotic, so theoretically bacteria should not develop resistance to it. A preliminary study showed that Nicomide-T gel is as effective as clindamycin gel in reducing blemishes.” Other research confirmed that it can protect the skin and is less likely to dry it than a number of other acne treatments. 11, 13 It is not clear whether Nicomide-T is as effective as Retin-A, though some studies conducted by the manufacturer, Sirius Laboratories, suggest that adding it to other treatments boosts the effectiveness of both.
Jul
2
Acne: Over-the-Counter Treatment
Benzoyl peroxide is the primary ingredient in most OTC acne treatments. This compound has antimicrobial activity and is usually quite effective for mild acne.
G. My teenage son has a mild case of acne, but to him it is huge. He washes with strong cleansers and uses a variety of acne medicines. Can you recommend something that will clear up his skin so he doesn’t scrub so much? His face is bright red after all the washing, and I don’t think that is good.
A. You’re right! Acne is not caused by dirt, so vigorous washing won’t help. It may even make things worse.
OTC benzoyl peroxide (Benzac, Clearasil Acne Treatment, Oxy 5, etc.) should do the job. If not, your son should see a dermatologist. Retin-A (tretinoin) and/or antibiotics can work wonders.
Benzoyl peroxide is found in a number of different products, from cleansing bars and liquid cleansers to lotions and even shaving creams. Read the instructions on the label and follow them; the procedure varies a little for the different forms. Benzoyl peroxide can dry the skin and cause irritation. If that happens, use it a little less frequently or look for a product with a lower concentration of the ingredient. Some Benzoyl Peroxide
Benzoyl peroxide unplugs pores and discourages thegrowth of skin bacteria. It is not, however, an antibiotic, and skin bacteria don’t seem to develop resistance to it.. Follow the instructions on the product label for application and use.
Side effects: Skin irritation, dryness, redness, scaling, and rash
Downside: Acne may worsen initially before improving. Use the product for 6 weeks to 2 months to evaluate its effectiveness..
Cost: Varies, depending on - the product; approximately $20 to $30 for a month’s worth of gel .
individuals are allergic to benzoyl peroxide and break out in hives or swelling, so try it out on your forearm first to make sure you will not react badly. If you do, you will have to forgo benzoyl peroxide treatment and look for another way to manage your acne.
A few nonprescription acne products contain active ingredients other than benzoyl peroxide. Resorcinol is generally used in combination with sulfur (Clearasil Adult Care contains them both). Salicylic acid is also found in some OTC acne products. None of these should be used in combination with benzoyl peroxide. All may irritate and dry the skin, and they should not be combined with other products that might irritate the skin.