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Abilify used for the treatment of acute episodes of schizophrenia (including as maintenance funds). Buy Abilify only after consulting with your doctor.
Abilify also used to treat acute manic episodes of bipolar disorder type I, including patients who have recently given mixed or manic episode (maintenance).
Contra Abilify
Abilify is contraindicated in patients under 18 years of age and patients with hypersensitivity to any component of the drug.
Side effects Abilify
Abilify can cause the certain side effects (check with your doctor)
International name:
Aripiprazole
Group Affiliation:
Antipsychotic (neuroleptic)
Description of the active substance (INN):
Aripiprazole
Description of the product brand name:
Abilify
Dosage form:
Tablets
Pharmacological Effects:
Neuroleptic. Presumably the therapeutic effect of aripiprazole in schizophrenia is caused by a combination of partial agonist activity on D2 dopamine and serotonin receptors 5NT1a and antagonistic activity against 5NT2 serotonin receptor. Aripiprazole has a high affinity in vitro to the D2 and D3 dopamine receptors, and 5NT1a 5NT2a serotonin receptors and moderate affinity for dopamine D4, 5NT2s 5NT7 and serotonin, alpha 1-adrenoreceptors and H1 histamine receptors. Aripiprazole is also characterized by a moderate affinity for serotonin reuptake sites and the lack of affinity for muscarinic receptors. Aripiprazole in animal experiments showed antagonism against dopaminergic hyperactivity and dopaminergic agonism against gipoaktivnosti. Interaction not only with dopamine and serotonin receptors explains some of the clinical effects of aripiprazole.
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Indications:
An acute attack of schizophrenia, as well as for maintenance therapy. Acute manic episodes of bipolar disorder type I and for maintenance therapy in patients with bipolar disorder type I, has recently suffered a manic or mixed episode.
Contraindications:
Hypersensitivity, the age of 18 years, during lactation.
Dosage and administration:
Inside, regardless of the meal, a once a day. Schizophrenia: initial dose 10-15 mg / day maintenance dose - 15 mg / day in clinical trials, the effectiveness of the drug in doses ranging from 10 to 30 mg / day. Manic episodes in bipolar disorder: initial dose 15-30 mg / day. If necessary, dose adjustment is carried out at intervals of not less than 24 h. In clinical studies demonstrated efficacy at doses of 15-30 mg / day with a manic episode at the reception for 3-12 weeks. Safety of doses above 30 mg / day in clinical trials has not been evaluated. Dose adjustment in patients older than 65 years, as well as in chronic renal failure and hepatic failure (class A, B and C on the classification of Child-Pyuga) is not required.
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