Anaemia is essentially a deficiency of red blood cells, and may occur as the result of a lack of certain factors such as iron, folic acid or vitamin B, or from disease in which the rate of breakdown of red cells exceeds the rate of production of new cells. Iron-deficiency anaemia is the most common form, and may occur during pregnancy or as a consequence of restricted diets. Such a deficiency can be dealt with by the oral administration of a suitable iron salt, and ferrous sulphate is widely used. For patients who cannot tolerate ferrous sulphate, other salts are ferrous gluconate and fumarate. Some iron preparations for use during pregnancy also contain folic acid but are too numerous to list here. Slow-release iron products are also available. In all cases of iron-deficiency anaemia, oral treatment should be continued for some months to build up an adequate store of iron.
In a few cases, where oral iron therapy is not possible, iron-deficiency anaemia can be treated with iron-sorbitol solution by deep i.m. injection, using a ‘Z’ technique to avoid staining the skin. The dose is based on the degree of iron-deficiency. Oral iron should be stopped for at least 24 hours before injection treatment. (Jectofer).
Megaloblastic anaemias are less common, and are due to a deficiency of vitamin B,, or of folic acid, or to a defect in the absorption or utilization of those factors, and may be secondary to treatment with cytotoxic agents such as methotrexate. Pernicious anaemia is the most common form of vitamin B12 deficiency, and develops insidiously as the normally ample stores of the vitamin in the liver are slowly depleted. Treatment is replacement therapy with hydroxocobalamin, which is the preferred form of vitamin BIZ, as it is excreted more slowly than the older cyanocobalamin, and has a much longer action. Some oral preparations of vitamin B,, are available, but in general they are regarded as unsatisfactory for the treatment of vitamin B12 deficiency.
Aplastic anaemia is due to a marked reduction in the formation of red blood cell precursors, and is a disease of the bone marrow. It may occur from no known cause, or from exposure to some toxic agents, including cytotoxic drugs. Bone marrow transplants are the only effective treatment, although some androgens such as nandrolone have been used with occasional success. Sideroblastic anaemias are due to a disturbance in the normal utilization of iron, and may respond to large doses of pyridoxine. Haemolytic anaemia is characterized by an excessive breakdown of red blood cells, due to disease or toxic agents. Some of these less common anaemias may respond to corticosteroid therapy. The severe anaemia of end-stage renal disease in dialyzed patients differs from other anaemias in being due to a lack of erythropoietin, the kidney hormone that regulates red blood cell production by the bone marrow. It can now be treated with human erythropoietin obtained by recombinant DNA.

Approved names    Brand names
ferrous sulphate    Feospan
Ferrograd sustained release products
Slow
ferrous fumarate Fersaday Fersamol Galfer
ferrous gluconate
ferrous glycine sulphate    Plesmet
Ferrocontin Continus
(sustained release product)
ferrous succinate    Ferromyn
iron - polysaccharide complex    Niferex
sodium iron edetate    Sytron
iron-sorbitol injection    Jectofer
hydroxocobalamin    Cobalin-H, Neo-Cytamen
cyanocobalamin    Cytacon (oral), Cytamen
nandrolone    Deca-Durabolin
pyridoxine
epoetin (erythropoietin)    Eprex, Recormon

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