May

30

Generic Drugs: Is There a Difference Between Generic Drugs and Brand?

May 30, 2011 | Leave a Comment

Before patients buy generic drugs online they want to know the answers to some of their questions, regarding generics. Why can one buy generic drugs cheap? Are generic drugs effective? Where can I buy generic drugs without a prescription cheap?

Today a lot of online pharmacies offer cheap generic drugs without a prescription and thousands of patients around the world take the opportunity to save on very expensive brand medications from a local pharmacy store. Generics are full analogues of brand ones, but are available to order online cheaper. Online pharmacies sell some drugs without a prescription which makes generic drugs purchase online even more convenient as you do not have to see a doctor.

Patients of all age groups and walks of life want to be treated effective and quality medicine. But here’s to suit all your medicines in different ways: some prefer to buy expensive original drugs, while others believe that lower-cost counterparts in no way inferior to well-known brands. In short, demand is there for any kind of drugs, as ill and eating a man does not stop never. What to and enjoy all kinds of pharmaceutical companies, letting the world market many drugs under various trade names.

According to recent statistics, the proportion of generic counterparts of drugs (generics) in the markets of many countries will only increase. Although the dynamics of growth is not the same: if the U.S. resorted to the use of generic drugs in approximately 15% of the treatment of diseases in Europe - 40-50%, in the post-Soviet countries - up to 80-90%. But do not be afraid of these numbers. Because generic - a quality product, which according to its pharmacological data of the original copies. The active substance in the analog and the original is absolutely identical. But the price of drugs is much different. And obviously for the benefit of generics. Why is this happening? To do this, to understand the differences in the production of both options medication.

When a pharmaceutical company synthesized a new drug, it is patent the name and performs a full spectrum of possible research - from clinical to experimental. Their progress is determined by: the exact formula, the effectiveness of the drug and all its side effects. At this preliminary stage can take up to 10 years. If we consider that a patent for the drug is given by an average of 20 years (sometimes 25), then for the remaining 10-15 years “exclusive use” producer has to invest heavily in the campaign, so with the help of massive purchases “recapture” the cost of wasted millions to test and make a profit. It is clear that the original price of such drugs will be essential.

What happens after the expiration of a patent? Right to manufacture the same drug, but under a different name may acquire any other company. Since emerging on the market, for example, not nootropil, and piracetam. This medicine is an exact copy of an analog, but since its production has already spent far less money, and it determines the selling price, which is an order of magnitude lower. So the generic - a kind of high-quality tracing paper once a patented drug, but at an affordable cost for a wide range of customers.

Dzhenericheskie drugs all over the world before they go on sale are thoroughly tested for compliance with the equivalence of the original drug. Such a study is conducted in three areas:

Pharmaceuticals - medicines should:
contain the same active ingredients;
introduced an identical manner;
be similar in concentration and its effect on the body.
Biological - the deviation between the analogs and copies are allowed no more than 15-20% of such parameters:
period of drug intake;
time to reach maximum concentration;
type and duration of excretion from the body.
Clinical - generic shall match the original for these indicators:
active substance;
security;
efficiency.

Thus, the generic is a quality drug, which contains the same active ingredient as the original drug, same adjuvants and production technology.

Summarizing the above, conclusions can be drawn: the use of generic drugs is absolutely justified, since it gives the doctor and patient choice; can treat almost all people from different walks of life, available in a price range, efficient and safe. In addition, taking a growing niche market of medicines, generic drugs stimulate the company’s original look promising new directions in drug development.

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May

26

Treatment of Erectile Dysfunction

May 26, 2011 | Leave a Comment

Treatment of erectile dysfunction. ED drugs online.

Note:ED drugs are the medications for the treatment of erectyle dysfunction (described in this article). Online pharmacy sells the most effective and popular ED drugs without a prescription: Viagra, Cialis and Levitra. You do not need a prescription to buy impotence treatment drugs in internet and online Viagra, Cialis and Levitra prices are really low depending on the quantity of pills you are buying. There is a special discount for all the returning customers who buy ED drugs. Flexible discount system makes Viagra price as well as Cialis and Levitra one of the lowest online with the highest qualit of products guaranteed.

Weak erection or erectile dysfunction
Sexual health is an integral part of human health and determine the quality of its physical and personality, psycho-emotional, intellectual and social functions.

Weak erection (impotence) - impotence, inability of a man to perform a full sexual intercourse and achieve sexual satisfaction for both partners.

The notion of weak erection or “erectile dysfunction” was suggested instead the term “impotence” in 1988 and includes the inability to achieve or maintain penile erection sufficient for satisfactory (ie, satisfying for both partners), sexual intercourse. Erectile dysfunction may be associated with decreased sexual desire, a violation of ejaculation and orgasm.

What is a weak erection or “erectile dysfunction”

The weak erections or erectile dysfunction, “say only if erection problems exist for a long period (3-6 months).

According to the most recent data, erectile dysfunction affects about 50% of men aged 40 to 70 years.

According to experts, one of the most common sexual disorders in men is weak erection or erectile dysfunction (ED), which is understood as the inability to achieve and (or) maintain an erection sufficient for sexual intercourse. About 150 million men worldwide suffer from this disease, and it is assumed that within the next 25 years this figure could double. This is partly explained by the steady increase in the prevalence of risk factors of ED, including the leading role played by diabetes and cardiovascular disease.

Despite the aging population in developed countries, most disorders of erectile function should be expected in men in developing economies due to high levels of stress and certain deficiencies in health care, especially preventive care.

According to statistics, up to 60% of men aged 30 to 45 years in varying degrees, a decline of erection.
Weak erection or erectile dysfunction or impotence?

Erectile dysfunction, aka impotence, is observed in every five men on the planet.
What is erectile dysfunction?

Currently, erectile dysfunction is defined as the inability to achieve and maintain an erection sufficient for sexual intercourse. This name was replaced by the less accurate and injuring more than men, the term “impotence”. Erectile Dysfunction: the inability to achieve an erection or keep it at a level sufficient for the commission of coitus. Distinguish between primary and secondary erectile dysfunction. In the primary male erectile dysfunction
in general never in his life was unable to perform sexual act, and in the secondary he managed it once or many times, before there was a violation. Secondary violation occurs about 10 times more likely than primary.
Who suffer from impotence, weak erections or erectile dysfunction. ”

Erectile dysfunction affects men of all ages, from adolescence. There is hardly a grown man, buyout ever in my life have suffered sexual failure. In most cases, young men aged 25-30 years, erectile dysfunction is psychogenic root cause, which in most cases successfully solved by sexologists psychologist. All causes of erectile dysfunction can be divided into two groups - organic, if there is any breach in the body, and psychological, that caused only features of the patient’s mind.

For psychological erectile dysfunction is characterized by:

* Sudden onset
* Night spontaneous erections reserved
* The problem of relations
* Problems in certain circumstances

For organic erectile dysfunction is characterized by:

* Gradual start
* Night spontaneous erections are absent
* Normal libido and ejaculation
* Problems under any circumstances

Treatment of erectile dysfunction, or violations of weak erection

If you clear the cause of the lack of an erection, then first of all try to resolve it themselves. Establish good relationships with a partner, stop abusing alcohol and nicotine. In all other cases, you should consult a physician urology, andrology, or sex therapist.

Only after a thorough medical examination may be decided on what treatment should be conducted in your particular case. Therapeutic options range from psychotherapy, medication and the use of special devices, prior to surgery (depending on the underlying disease). Each treatment has advantages and disadvantages. A doctor can tell in detail about all the alternative therapies. After that will be able to with him to decide which of these methods is
optimal from your point of view and in terms of your sexual partner.

Erectyle disfunction drugs (ED) are available to buy online without a prescription. The popular ED drugs are Viagra, Cialis and Levitra and their various variations.
ED drugs are the medications for the treatment of erectyle dysfunction (described in this article). Online pharmacy sells the most effective and popular ED drugs without a prescription: Viagra, Cialis and Levitra. You do not need a prescription to buy impotence treatment drugs in internet and online Viagra, Cialis and Levitra prices are really low depending on the quantity of pills you are buying. There is a special discount for all the returning customers who buy ED drugs. Flexible discount system makes Viagra price as well as Cialis and Levitra one of the lowest online with the highest qualit of products guaranteed. Enter online generic pharmacy if you want to purchase Cialis online, cheap Levitra and generic cheap Viagra.

Prostatitis and Viagra, Levitra, Cialis

Disorder in the sexual sphere are not only among the most common in the modern world, but also the most fatal to personal relationships, so drugs such as pill Viagra, Cialis and Levitra first come to mind at difficulties in sexual matters and as a treatment for prostatitis.

Viagra, Cialis and Levitra are used not only for violations of potency - they can be used to increase sexual capacity and exacerbation of sensations. However, initially the drug Viagra, Cialis and Levitra have been designed specifically as a means to combat erectile dysfunction. More than one year in some countries are made up of Viagra, Cialis and Levitra (generic), under other brands. Generics are identical in composition to Viagra, that is, it is sildenafil citrate, but the price for generics is several times lower.

In addition to erectile dysfunction, prostatitis and measures for its prevention and treatment are the main problem of men of all ages as well as the causes of prostatitis may be different. Doctors suggest that the use of Viagra does not cause any effect and has only a positive impact in this disease. Thus, Viagra, Cialis, Levitra - a complete life and sex, which brings only positive feelings.

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May

26

Antidepressants. Depression Treatment Drugs.

May 26, 2011 | Leave a Comment

The name itself speaks of such drugs - they are designed to treat depression. Such medications are always recommended as a first step in therapy for depression, from heavy to moderate, in combination with conversational therapy. An example is the cognitive-behavioral therapy.

Antidepressants are widely used in treating various mental disorders such as:

- Strong phobias such as agoraphobia and social,
- Panic disorder,
- Anxiety disorder
- Post Traumatic Stress Disorder,
- Anxiety disorder
- Bulimia.

In some cases, certain antidepressants such as tricyclics, were not developed initially as painkillers, but there is evidence of their effectiveness in treating chronic pain of a nervous nature. Chronic nerve pain that is often referred to as neuropathic, arise in the body as a result of damage to the normal state of the nerve and quite often, such pain can not be removed with the help of painkillers such as “Paracetamol”.

Very often, an antidepressant used to treat different cases of non neuropathic nature. And many experts in the medical field, consider them to be less effective for such purposes. Pain, are not associated with neurological disorders, with the help of antidepressants may be localized, especially for chronic pain in the neck and back, as well as fibromyalgia.

Depression. Unipolar depression, or as it is called clinical depression, can occur in almost any age, but most often it affects people in a range from 25 to 44 years, although sometimes observed in children aged 5-6 years. The total number of patients exposed to depression for about 20% of women and 10% of men. In the depressed person loses the capacity for work, lose interest in school, he may have much worse health. And the worst thing is that depression leads to commit suicide.

The difference between short periods of illness, clinical depression leads to constant changes in mood, which has a negative impact on self-esteem of man, his relationships with people, as well as the climate in the family. Depressive episodes occasionally occur and occur over many days and months, and in some cases even a few years. In a state of clinical depression will determine the following mental and physical factors:

- A sense of complete irrelevance, helplessness, hopelessness and despondency.
- Inability to concentrate and make decisions.
- Violation of the functions of sleep.
- Depressed mood (sadness, unexplained sadness).
- Loss of sexual interest.
- Loss of interest in everything that enjoyed previously. Loss of enjoyment of life.
- Loss of appetite, weight loss, or conversely, its set.
- Fatigue.

When conducting clinical diagnosis of depression, such symptoms are repeated consistently, at least for two weeks. But here we must remember that these symptoms may be the consequence of such widespread diseases as diabetes, hypertension, heart disease, etc. This suggests that depression may be a secondary symptom of another disease. The final diagnosis will be able to supply only a doctor after a long observation and careful examination.

So what is the cause of depression? Specific cause can not be called to this day. But conducted scientific studies have shown that depression is mated to an imbalance of certain chemicals, which are called neurotransmitters - namely, norepinephrine, serotonin and dopamine. Such neurotransmitters are widespread in many parts of the human brain and are designed to perform their specific neural functions.

The clinical study showed that patients with clinical depression do not have enough norepinephrine or serotonin in the limbic system of the brain. Also there is a large imbalance between these two neurotransmitters in the brain. Existing antidepressants are designed to increase the content of these neurotransmitters. In addition, some of them affect the level of dopamine in the brain regions. After receiving such drugs emotions and mood in patients should stabilize, and the person returns to a normal life. Like all medicines, antidepressants have side effects such as changes in blood pressure as well as they can interfere with some physiological functions of a person, such as sleep or appetite.

We must remember that:

- Everyone can easily find an antidepressant that will come to him personally.
- Six out of ten people will feel much better after the first use of selected antidepressant. Others to find the appropriate medication, will have to try different antidepressants.
- Existing antidepressants have both advantages and disadvantages, and as long as you do not start taking some of them, you can not know whether it helps you in combating depression.

Antidepressants are classified according to types of neurotransmitters, for which they work, as well as on the basis of these effects.

There are some types of antidepressants:

- Selective serotonin reuptake inhibitors (SSRIs)

These antidepressants have been widely used since the mid 1980’s, and most often prescribed for depression. This group of antidepressants makes it possible to block the return of serotonin back into the cell, which sends a nerve impulse. Such exposure increases the concentration of serotonin in the synaptic gap between nerve cells, thus greatly enhances the stimulation of postsynaptic cells, which takes the pulse.

The group of SSRIs includes the following products:

- Sertraline (Zoloft)
- Escitalopram (Lexapro)
- Fluvoxamine (Luvox)
- Citalopram (Celexa)
- Paroxetine (Paxil)
- Fluoxetine (Prozac)

In its effect, all these SSRIs are equally effective and tolerated almost equally. But, nevertheless, the response of individual patients to different chemical compounds individual. In this regard, some patients may experience some side effects after taking specific SSRIs. Among the side effects of antidepressants in this group are - insomnia, anxiety, dizziness, nausea and vomiting.

- Tricyclic antidepressants

Tricyclic antidepressants began to be applied in the late 1950’s - early 1960’s. As with SSRIs, tricyclic antidepressants block the reuptake of the neurotransmitter norepinephrine in the presynaptic nerve cells, and thus increases its free concentration.

The group of tricyclic antidepressants include:

- Amitriptyline (Elavil)
- Imipramine (Tofranil)
- Maprotiline (Lyudiomil)
- Nortriptyline (Pamelor)
- Desipramine (Norpramin)
- Clomipramine (Anafranil)

First and foremost, tricyclic antidepressants affect blood pressure and heart rate, as norepinephrine is involved in the activities of the autonomic nervous system that controls such functions. At the use of drugs in this group there are the following side effects - tachycardia, postural hypotension, dry mouth and urinary retention. Drugs in this group are used rarely because of their toxicity and danger of overdose. But for some patients who can not tolerate SSRIs or other antidipressants, tricyclic antidepressants are the way out. In order to avoid various side-effects during the treatment course required careful medical supervision.

- Selective serotonin reuptake inhibitors and norepinephrine

Production of drugs in this group began in mid-1990’s. The action of these drugs are based on blocking the reuptake of norepinephrine and serotonin. This group of drugs include:

- Duloxetine (Cymbalta)
- Venlafaxin (Effexor)
- Buprpion (Wellbutrin “,” Zyban “), which also blocks the reuptake of dopamine and norepinephrine

Side effekts the same as that of the SSRI, but expressed somewhat weaker, and the same drugs as duloxetine and buprion in terms of weight gain and sexual dysfunction in general have minimal impact.

- Monoamine oxidase inhibitors (MAOIs)

An enzyme called monoamine oxidase, leads to a reduction of norepinephrine and serotonin in the synaptic gap between neurons and presynaptic nerve cell.

This group includes the following products:

- Isocarboxazid (Marplan)
- Selegiline (Eldepril)
- Moclobemide (Manerix)
- Phenelzine (Nardil)
- Tranylcypromine (Parnat)

By adjusting the content of norepinephrine, these drugs cause several side effects that affect the cardiovascular system. Patients who take these antidepressants should limit consumption of products, which include tyramine. This is because the tyramine interaction with MAOIs, causing hypertension. Tyramine is a part of products such as sauerkraut, sausage, beef and chicken livers, soy sauce, dried meat and fish, cheese, yogurt, sour cream, figs and raisins. It is also necessary to refrain from drinking any alcoholic beverages.

- Noradrenergic and specific serotonergic antidepressant (HACC)

Antidepressants, which are produced at the present time, very well tolerated by patients, to help cope with anxiety and depression, and most importantly, they have significantly fewer side effects than previous generations of antidepressants.

Some of these drugs began to publish in mid-1980’s, and some have begun to produce more recently. Preparations of HACC reduce the rate of absorption of noradrenaline presynaptic nerve cell, and in turn increases its concentration in the free form. In addition, they provide the ability to block certain serotonin receptors, which significantly improves the “useful” serotonin neurotransmission.

The group of HACC include:

- Nefazodone (Serzon)
- Trazodone (Dezirel)
- Mianserin (Lerivon)
- Mirtazilin (Remeron)

Side effects of these drugs include dry mouth, drowsiness, increased appetite and weight gain. But these effects are mild result.

It should be good to remember that all currently existing antidepressants are equally good for treating depression. Starting a course of treatment must take into account the following factors - age, heredity, individual tolerance of drugs, the response to no more use drugs. Before applying the new antidepressants it is mandatory to consult a physician.

Publications by topic:
· Antidepressants
· Treatment with antidepressants
· Description antidepressants

Antidepressants belong to a large group of drugs, the main feature of which is the removal of the doldrums. Antidepressants include monoamine oxidase inhibitors: hydrazine (iprazid, Nialamide) and negidrazinovye derivatives (indopan, etc.), 4 - and 3-ring compounds (Mianserin, imipramine, amitriptyline, azafen, pirazidol), secondary amines (desipramine).

Isolated as a group of antidepressants II generation (nomifenzil, trazadon, etc.) and preparations of lithium.

Possible side effects: drowsiness, dry mouth, “a veil before the eyes, constipation, difficulty urinating, fainting, sweating, tremors, rashes, palpitations, headache.

Caution: When combined with certain medications and foods MAO inhibitors have the opposite effect, which can lead to a significant rise in blood pressure.

When antidepressant therapy in both groups and alcohol intake should be limited. Ask your doctor whether it is possible for antidepressants drive or other mechanisms.

More
Haibolee studied and security are the tricyclic compounds. The mechanism of action of tricyclic antidepressants is associated with the blockade of the reuptake of norepinephrine presynaptic nerve endings, resulting in the content of norepinephrine in the synaptic clefts increases.

In places the accumulation of noradrenaline (different brain structures, as well as heart and lungs, spleen and other organs) increases the activity of adrenergic nerve impulse transmission, excitation occurs the central and peripheral a-and b-adrenergic receptors.

A similar effect of 3-cyclic antidepressants be observed in the dopamine and serotonin. Drugs in this group blocking the central and peripheral M-cholinergic receptors, providing atropinopodobnoe action.

MAO inhibitors block monoamine oxidase Nialamide causing oxidative deamination and inactivation of monoamines (noradrenaline, dopamine, serotonin), with the accumulation of these amines in brain structures.

Some antidepressants combine the action of MAO inhibitors and 4 - and 3-cyclic compounds. Common property of all antidepressants is timolepticheskoe action: effects on affective with improved mood and overall mental state.

Do without the selection of drugs that reduce the severity of depression, almost never fails.

Lack of interest in what happens in the outside world, apathy, indifference, low mood, difficulty concentrating, amounting to a complete inability to concentrate, sometimes unwillingness to live with enormous difficulty overcome a teenager. Intolerance of depression is a major cause of relapse, even for those folks who genuinely want to give up drugs. A matter of choice of antidepressants - the question is absolutely doctor.

In most patients, even after treatment by the methods described above paid, retained or that symptoms of depression.

Below the names of three drugs, which seem to us best to treat depression caused by the abolition of drugs: Auroriks, Coaxil, Zoloft.

These drugs are designed on modern principles of the so-called metabolic therapy. They are not the “chemistry” in the domestic sense. Their effect on the metabolism due to the fact that they facilitate the body natural synthesis of some compounds (eg serotonin), lack of which in the nervous system leads to depression.

List the three drugs is located in the descending order of their effectiveness.

Aurorix and coaxil, inter alia, help the patient improve metabolism in the nerve cell. In their systematic reception improves memory, easier to focus, gradually leaving the feeling of constant fatigue.

We must remember that no anti-depressants, even the most modern and do not act immediately. The effect of the above drugs does not develop earlier than 7-10 days of reception. Are not anti-depressants and “substitutes” of drugs. No special feelings for the first person to receive not feel. They are designed to gradually and imperceptibly the normalization of the mental state of the patient.

In principle, due to the fact that these antidepressants are not addictive and have virtually no side effects (except in cases of individual intolerance), you can start using them without consulting your doctor. But it is necessary to take into account two factors:

First, the best anti-depressant may be a doctor.

Secondly, the very state of depression - it is an occasion to persuade the patient to see a doctor. Teen bad … In the depression, he is aware of this. If you can give anti-depressants, he gets better, and a visit to the doctor begins to be postponed indefinitely. When a person feels well, to persuade him to systematically treated much more difficult.

Abolition of heroin addict will take more easily than usual. In his mind is not put off your words and warnings and the fact that with the help of pills, which gave the mother, it is easy to “jump out of the system.” As a result of an attempt to help in self-control drug addict with depression may result in relapse and even greater difficulties with the adoption of a teenager a final decision to quit drugs.
Melipraminum (imipramine, antideprin, imipramine) refers to the strong antidepressants with concomitant stimulant.

Pharmacokinetics.
The drug is well absorbed when taken orally, reaches maximum concentration in the blood 1-2 hours after intramuscular injection, 30-60 minutes. Hakaplivaetsya in the liver, kidneys and brain. Well penetrates the blood-brain barrier. Relationship with protein 76-95%. Actively metabolized in the liver, excreted in the urine. The half-life 9-20h. Testimony. Melipraminum used in depressive states of various etiologies: asthenic-depressive states of endogenous depression in patients with manic-depressive psychosis, reactive depression, depression with psychopathy, neuroses, as well as enuresis.

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May

26

Diuretics

May 26, 2011 | Leave a Comment

Diuretics

COMMON DIURETICS

• Bendroflumethiazide (Naturetin)
• Benzthiazide (Exna)
• Bumetanide (Bumex)
• Chlorothiazide (Diuril, Diachlor, Diurigen)
• Chlorthalidone (Hygroton)
• Ethacrynic acid (Edecrin)
• Furosemide (Lasix)
• Hydrochlorothiazide (Esidrix, HCTZ, HydroDIURIL, Oretic)
• Hydroflumethiazide (Diucardin)
• Indapamide (Lozol)
• Methyclothiazide (Aquatensen, Enduron)
• Polythiazide (Renese)
• Trichlormethiazide (Diurese, Metahydrin, Naqua)

The first real breakthrough in the treatment of high blood pressure occurred in 1958. That was when chlorothiazide was introduced. Before this “thiazide” diuretic was developed, physicians admonished patients to eliminate salt from their diets. It was one of their few treatment options and was only partially effective. Other available drugs like reserpine, which was derived from the Rauwolfia serpentine plant, often caused very serious side effects such as suicidal depression.
Although chlorothiazide and similar compounds started a revolution in blood pressure treatment, they eventually lost their luster. Newer medications like beta-blockers, calcium channel blockers, and ACE inhibitors seemed sexier and more powerful. Since diuretics were old and available generically, drug companies promoted the new, more expensive products. And physicians responded by prescribing Tenormin (atenolol) or Procardia (nifedipine). We now know that such drugs are not better and may even be worse than old-fashioned, unglamorous diuretics. This government-sponsored study, which cost $120 million, tracked more than 40,000 subjects for years to determine the outcomes of various blood pressure–lowering drugs scientists found that chlorthalidone, an inexpensive diuretic, was superior to some popular brand-name blood pressure pills.

The pharmaceutical industry had spent billions investigating and promoting products like Norvasc (amlodipine), Cardura (doxazosin),  and Prinivil (lisinopril). For FDA approval, drug companies need only prove that a medicine lowers blood pressure more effectively than placebo. They have little incentive to test medications head-to-head to determine how
they compare in improving health.
That’s what makes this government research so important. Instead of just looking at numbers on a blood pressure monitor, scientists determined whether people had suffered heart attacks, strokes, or heart failure or had died. Curt Furberg, MD, PhD, chair of the study’s steering committee, shared his conclusions with us: “It’s important to lower blood pressure, but it matters how you do it. The diuretics have three advantages. They are unsurpassed in lowering blood pressure; they are superior in reducing the cardiovascular complications of hypertension; and they are 10 to 20 times cheaper than the newer branded drugs.” Doctors were probably astonished to learn that in this trial the alpha-blocker Cardura (doxazosin) actually increased the likelihood of heart failure compared with diuretic treatment.

Chlorthalidone

Many physicians believe that all thiazide diuretics are created equal. Hydrochlorothiazide (Esidrix, HCTZ, Oretic) is the most widely prescribed by far. Although it is unquestionably effective, we prefer chlorthalidone. For one thing, it was the thiazide diuretic used in the ALLHAT that proved so beneficial in reducing strokes and other cardiovascular events. For another, chlorthalidone remains in the body longer than other thiazides and may be more effective in controlling blood pressure, especially during the
night.

Downside: Increased urination, since this is part of the way the drug works. Sexual dysfunction may be more likely than with some other blood pressure meds.

Side effects:
• Muscle cramps
• Difficulty breathing
• Confusion
• Mood changes
• Lethargy, fatigue
• Weakness
• Dry mouth, thirst
• Nausea, vomiting
• Irregular heart rhythm
• Symptoms are not a reliable indicator. Blood tests are essential.

Of course no one should ever discontinue any blood pressure medication without careful consultation with and supervision by a physician. Norvasc and similar drugs do have an important role in some heart conditions. But ALLHAT suggested that not all blood pressure medicines are created equal.
As much as we value thiazide diuretics in general, and chlorthalidone in particular, these are not perfect blood pressure–lowering drugs. Although they are inexpensive and effective, they can cause several serious side effects. One potential complication of diuretic treatment is elevation of blood sugar levels, which can lead to an increased risk of diabetes.
The biggest complication, however, is depletion of the essential minerals magnesium and potassium. It is important to have blood tests regularly to measure both of these electrolytes and make sure they are maintained within normal limits. Allowing the level of magnesium or potassium to stay low has serious negative health consequences. Both minerals must be kept in proper balance.
To get around the loss of potassium caused by many thiazide-type diuretics, physicians have switched to potassium-preserving diuretics such as amiloride (Midamor), spironolactone (Aldactone), and triamterene (Dyrenium).They are prescribed alone or more commonly in combination with hydrochlorothiazide (Aldactazide, Dyazide, Maxzide, and Moduretic). Such drugs have some of the same adverse reactions and precautions that standard diuretics have.
Potassium-preserving diuretics pose a significant problem when combined with ACE inhibitors such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), quinapril (Accupril), and ramipril (Altace). Because the ACE inhibitors also help the body retain potassium, it is possible that one could end up with potassium overload. This is just as dangerous as too little potassium. Symptoms may include breathing difficulty, weakness, confusion, slow heart rate, and potentially life-threatening heart rhythm changes. Periodic blood tests are essential for a doctor to monitor the safe use of these medicines.

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May

24

Diflucan (Fluconazole) and Other Antifungals

May 24, 2011 | Leave a Comment

Order Diflucan 150, 100 and 200 mg cheap without prescription. Generic Diflucan online order and other effective antifungal prescription drugs online without a prescription. Fluconazole internet purchase fast delivery

Diflucan (Fluconazole) and Other Azole Antifungals

Type of Drug: Azole Antifungals (Diflucan, Fluconazole)

Brand Names: Diflucan

Generic Ingredient: Fluconazole Diflucan

Generic Ingredient: Itraconazole Sporanox Ketoconazole Extina  Nizoral Ketozole Xolegel Posaconazole Noxafil Voriconazole Wend

Prescribed For: Fungal infections of the blood, mouth, throat, vagina, or central nervous system.

Fluconazole, posaconazole, and itraconazole can be used to treat opportunistic fungal infections that inflict many people with HIV or cancer whose immune systems have been compromised.

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General Information

Azole antifungals are used to treat a variety of fungal organisms, including Candida, aspergillus, cryptococcus, blastomycosis, fusarium, histoplasmosis, and Scedosporium. They work by inhibiting important enzyme systems in the organisms they attack. These drugs are broken down in the liver.

Cautions and Warnings

Do not take azole antifungals if you are allergic or sensitive to any of their ingredients. People who are allergic to similar antifungals may also be allergic to these drugs, but cross-reactions are not common and serious allergic reaction is rare.
Azole antifungals can affect heart rhythm and should be used with caution if you have a history of abnormal heart rhythms.
Rarely, azole antifungals can cause liver damage. The drugs should be used with caution in people with liver disease. At least one in every 10,000 people who take ketOGonazole develop liver inflammation. The inflammation generally subsides when the drug is discontinued.
Voriconazole tablets contain lactose. They should not be taken by patients with rare hereditary problems of galactose intolerance, Lapp-lactase deficiency, or glucose-galactose malabsorption.
Rash may be an important sign of drug toxicity, especially in people with HIV or others with compromised immune function. Report any rashes, especially ones that do not heal readily, to your doctor.
These drugs can have very serious effects if combined with other medicines. See “Drug Interactions” for specific information.

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Possible Side Effects

Side effects are generally more common among people with HIV.

Generic Diflucan Fluconazole (Diflucan 100 mg, 150 mg and 250 mg)

Less common: liver toxicity, as measured by increases in specific lab tests. These changes in lab values are more common in people with HIV or cancer, who are more likely to be taking several drugs.

Rare: seizures and exfoliative skin disorders. People with
HIV or cancer who take fluconazole for fungal infections
may develop severe liver or skin problems. Contact your
doctor if you experience any side effect not listed above.
Itraconazole
•    Most common: nausea, vomiting, and rash.
Less common: diarrhea, abdominal pain, appetite loss, swelling in the legs or feet, fatigue, fever, feeling unwell, itching, headache, dizziness, reduced sex drive,     tiredness, high blood pressure, liver or kidney function abnormalities, low blood potassium, and impotence.
Rare: gas, sleeplessness, depression, ringing or buzzing in the ears, bronchitis, chest pain, coughing, and swollen or painful breasts in men or women. Contact your doctor if you experience any side effect not listed above.

Usual Dose

Fluconazole (generic Diflucan)
Adult and Child (age 14 and over): Diflucan 100-400 mg once a day. Child: Diflucan 1.3-5.5 mg per lb. of body weight once a day; no more
than 400 mg Diflucan a day.

Overdosage
Overdose is likely to result in exaggerated drug side effects. Doses of posaconazole up to 1600 mg a day have been taken without any adverse reactions. Take the victim to a hospital emergency room. ALWAYS bring the prescription bottle or container.

When taking generic Diflucan fluconazole, regular doctor visits are necessary to monitor liver function and general progress. Call your doctor if you develop severe diarrhea; vomiting; reddening, loosening, blistering, or peeling of the skin; darkening of the urine; jaundice (yellowing of the skin or whites of the eyes); loss of appetite; or abdominal pain, especially on the right side. Report other symptoms that are bothersome or persistent.
Itraconazole must be taken for at least 3 months to determine its effectiveness; otherwise, the infection may return.
If you forget a dose of one of these medicines, take it as soon as you remember. If it is almost time for your next dose, skip the one you forgot and continue with your regular schedule. Do not take a double dose.

Special Populations

Pregnancy/Breast-feeding: Animal studies with Diflucan show effects on the fetus that have not been seen in humans. Pregnant women should not use azole antifungals unless the possible benefits outweigh the risks.
These drugs pass into breast milk. Nursing mothers who must these drugs should use infant formula.
Seniors: Seniors may require a reduced dosage of fluconazole due to age-related loss of kidney function. No dosage adjustments are necessary with other azole antifungals.

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May

23

DRUGS DEFEATING IMPOTENCE IN CASE OF PROSTATE PROBLEMS

May 23, 2011 | Leave a Comment

SOME DRUGS CAN DEFEAT IMPOTENCE

Today the answer is simple - viagra, cialis, levitra. Nothing has ever been better or more efficient in fighting impotence or erectile dysfunction.  You can buy these drugs online without prescription at cheaper prices than offline. These three drugs has shown amazing effect in impotence treatment and their invention some years ago has become an inportant social effect which has literally changed the world.
There are other drugs that can be used to help an impotent man. One of them is called papaverine, and many urologists suggest its use. The drug is injected directly into the side of the penis. This drug causes a dilation of arteries in the penis thereby increasing the flow of blood to the penis and also causes less blood to leave the penis.
Blood is what causes an erection, and with the increased flow, many impotent men are able to achieve a firm erection and subsequent intercourse.
The patient is given the first injection in the office to teach him how to do it. A skinny needle is used and there is no pain involved. The medication will cause a temporary burning sensation but it’s not severe.
Sometimes a patient has psychological problems involved with his impotence. Papaverine is especially good in these cases. By injecting himself, the patient achieves and maintains an erection for up to an hour. This will naturally reduce the fear of failure which results so often in a poor performance anxiety.
Some urologists gradually reduce the dosage and frequency of the shots. For patients with purely psychological impotency problems this can result in a return to normal sexual function without any shots.
Another drug, Prostaglandins, is also being used for penile injections to help in impotency. It is also a vein-dilating medication and works much the same way that Papaverine does.
What about the over the counter aphrodisiacs that can be found in many health food stores? Most aren’t labeled as such, but the advertising or the labels suggesting a vigor for life, and an elixir especially for men, tell what they are selling.
The Food and Drug Administration has simply banned all aphrodisiacs from sale with the explanation that they do not do what they claim. Most still sold don’t help, but don’t do that much harm. Here you have to remember the placebo effect. If a sugar pill will help a man to get a workable erection, use it and don’t ask questions.
One old folk remedy, however, is being talked about by some serious researchers and physicians. This is yohimbine. It comes in a pill form and some doctors say it can help restore function and desire in some men. It is said to dilate blocked blood vessels and helps in the release of norepinephrine. Doctors say this compound is helpful in causing and maintaining erections. We expect to hear more about this yohimbine in the years ahead.

Today, however, the great trio: Viagra, Cialis and Levitra are widely available on the market and are considered to be the best remedies in erectyle disfunction treatment. If you have prostate problems, consult your doctor on cialis, viagra or levitra use for this particular case.

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May

22

Zithromax (Azithromycin)

May 22, 2011 | Leave a Comment

Generic Name: Azithromycin
Brand Names: Zithromax,  Zmax

Type of Drug: Macrolide antibiotic.

Prescribed For:
Upper and lower respiratory tract infections, skin infections, sexually transmitted diseases (STDs), middle eat Intections, tonsillitis, pharyngitis,  bacterial sinusitis.

General Information:
Azithromycin is an azalide antibiotic, a subgroup of the macrolides. Macrolide drugs are either bactericidal (bacteria-killing) or bacteriostatic (inhibiting bacterial growth) depending on the organism in question and amount of antibiotic present.

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Cautions and Warnings
Do not take azithromycin if you are allergic or sensitive to any of its ingredients or any macrolide antibiotic.
is excreted primarily through the liver. People with liver disease or damage should consult their doctors. Those on long-term therapy with this drug should have periodic blood tests.
Colitis (bowel inflammation), ranging from mild to life-threatening, has been associated with all antibiotics (see “Possible Side Effects”).
Azithromycin is considered appropriate only for the treatment of more mild forms of pneumonia in non-hospitalized patients. People with other underlying conditions, those who are immune-compromised, and those who contract pneumonia in a hospital or other institutional setting probably should be treated with other antibiotics. No prescription Zithromax is now possible to obtain online at an internet pharmacy as well as any of more than 400 popular generic drugs. Get whatever dosage you need for your treatment you can buy it: Zithromax 500mg or Azithromycin (generic Zithromax) 250 or 100 mg are available to order cheaply. The more pills you buy the cheaper they are going to cost you. You can check the prices and choose the amount of Zithromax you require and then make a secure order. Your order will reach you in about 5-6 days.

Zithromax Possible Side Effects
Most side effects are mild and go away once you stop taking azithromycin.
Most common: nausea, vomiting, abdominal pain, and diarrhea. Colitis (symptoms include severe abdominal cramps and severe, persistent, and possibly bloody diarrhea) may     develop.
Less common: heart palpitations; chest pain; vaginal irritation; stomach upset; gas; dizziness; headache; tiredness; unusual sun sensitivity; rash; itching; swelling;         fungal infection of the mouth or vagina; dark, tarry stools; kidney inflammation; and vertigo.

Zithromax Drug Interactions
•    Pimozide should not be taken by anyone also taking a macrolide antibiotic. Two people died while taking this combination.
•    Antacid products containing aluminum magnesium may delay azithromycin into the blood. Separate your antacid dose from Zithromax by at least 1 hour.
•    All macrolide antibiotics increase blood levels of cyclosporine and may cause kidney damage.

•    Combining Zithromax and a statin cholesterol-lowering drug increases the risk of developing a painful and potentially fatal condition involving severe muscle degeneration.
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Food Interactions:
It is important to take Zithromax azithromycin liquid on an empty stomach, 1 hour before or 2 hours after meals. Tablets may be taken with or without food.

Usual Dose of Zithromax:
Respiratory Tract Infections, Skin Infections, STDs, and Bacterial Sinusitis
Adult (age 16 and over): Zithromax500 mg as a single dose for 3 days, or 500 mg as a single dose on day 1, then Zithromax 250 mg once a day on days 2-5 of treatment. STDs are treated with a single dose of 1000-2000 mg.
Middle Ear Infections and Bacterial Sinusitis* (Child)
1 -Day Regimen: 13.6 mg per lb. of body weight a day for 1 day. 3-Day Regimen: 4.5 mg per lb. of body weight a day for 3 days. 5-Day Regimen: 4.5 mg per lb. of body weight a day for day 1,
and 2.25 mg per lb. a day for days 2-5. 3-day regimen for bacterial sinusitis preferred.
Tonsillitis and Sore Throat
Child (age 2 and over): 5.5 mg per lb. of body weight a day for 5 days.

Overdosage
Overdose may cause severe side effects, especially nausea, vomiting, stomach cramps, and diarrhea. Call your local poison control center or hospital emergency room for more information. If you seek treatment, ALWAYS bring the prescription bottle of Zithromax pills or container.

Special Information
Call your doctor if you develop nausea, vomiting, diarrhea, stomach cramps, or severe abdominal pain. Stop taking Zithromax drug and immediately call your doctor it you experience breathing difficulties, chest pain, hives, rash, itching, mouth sores, or unusual sensitivity to light.
It is crucial that you follow your doctor’s directions on how to take the drug and how many days to take it—even if you feel well sooner. This drug’s effectiveness may be severely reduced otherwise. Taking azithromycin at the same time each day may help you remember your medication.

If you forget a dose of azithromycin Zithromax, take it as soon as you remember. If it is almost time for your next dose, skip the dose you forgot and go back to your regular schedule.

Special Populations:
Pregnancy/Breast-feeding: It is not known if azithromycin taken during pregnancy will harm a fetus. This medication should be taken by pregnant women only if it is clearly needed.
It is not known if Zithromax passes into breast milk, but other macrolide antibiotics do. Nursing mothers who must take this drug should use infant formula.
Seniors: Seniors with liver disease should use caution. Seniors who have pneumonia or are especially sickly or debilitated probably should be treated with other medications.

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May

21

Tenormin (Atenolol)

May 21, 2011 | Leave a Comment

Tenormin (Atenolol)

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Generic Name: Atenolol
Brand Name: Tenormin
Generic Ingredients: Tenormin + Chlorthalidone Tenoretic
Generic Ingredient: Nebivolol Systolic
Type of Drug: Beta-adrenergic blocking agent.

Prescribed For: Tenormin alone or in combination is prescribed for high blood pressure, abnormal heart rhythms, angina pectoris, and prevention of second heart attack and migraine. It is also usedto treat alcohol withdrawal, stage Ifight, and other anxieties. Nebivolol is currently approved only to treat high blood pressure. Both are used together with other blood-pressure-lowering medications.

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General Information

Tenormin is one of many beta-adrenergic blocking drugs, or beta blockers and primarily blocks the beta, receptor. Nebivolol blocks both the beta, and beta, receptors when taken at high doses by people whose liver breaks down the drug more slowly than average. These drugs interfere with the action of adrenaline and other chemicals in the body that affect many body functions. Individual beta blockers have different characteristics that can make them more suitable for certain conditions or people.
When used to treat high blood pressure, Tenormin may be used either alone or concurrently with other antihypertensive drugs, particularly with a thiazide-type diuretic.

Cautions and Warnings

Do not take these drugs it you are allergic or sensitive to any of their ingredients or to other beta blockers. People with a severe allergy to any substance may be more sensitive to that allergen while taking a beta blocker.
People with angina who take these medicines for high blood pressure risk aggravating their angina if they suddenly stop taking the drug. These people should have their drug dosage reduced gradually over 1-2 weeks.
Tenormin should not be used by those with slow heartbeat, moderate to severe heart block (a condition affecting the heart’s conduction system), congestive heart failure unless it is due to a quickened heart rate that can be treated with Tenormin, or acute heart failure.
Tenormin and nebivolol should be used with caution if you have liver or kidney disease, because your ability to eliminate these drugs from your body may be impaired. Dose adjustments may be needed.
These drugs reduce the amount of blood the heart pumps. This reduction in blood flow may aggravate the condition of people with poor circulation or circulatory disease.
If you are undergoing major surgery, your doctor may want you to stop taking these drugs at least 2 days before surgery.
If you have pheochromocytoma (adrenal gland tumor), use Tenormin with caution.
Tenormin should be usedOfti caution in those with chronic bronchitis, emphysema, or other nonallergic bronchospastic diseases.
People with a history of severe anaphylactic reaction to allergens may be unresponsive to usual doses of epinephrine while taking beta blockers.

Possible Side Effects

Tenormin

Side effects are relatively uncommon and usually mild; they usually develop early in the course of treatment and are rarely a reason to stop taking Tenormin.
Most common: impotence.
Less common: unusual tiredness or weakness, slow heartbeat, heart failure (symptoms include swelling of the legs, ankles, or feet), dizziness, breathing difficulties,      bronchospasm, depression, confusion, anxiety, nervousness, sleeplessness, disorientation, short-term memory loss, emotional instability, cold hands and feet, constipation,      diarrhea, nausea, vomiting, upset stomach, increased sweating, urinary difficulties, cramps, blurred vision, rash, hair loss, stuffy nose, facial swelling, itching, chest      pain, back or joint pain, colitis, drug allergy (symptoms include fever and sore throat), and liver toxicity.
Rare: lupus erythematosus (chronic condition affecting the body’s connective tissue). Contact your doctor if you experience any side effect not listed above.

Drug Interactions

•    Tenormin may interact with surgical anesthetics to increase the risk of heart problems during surgery. Some anesthesiologists recommend gradually stopping the drug by 2          days before surgery.
•    Tenormin may interfere with the normal signs of low blood sugar and with oral antidiabetic drugs.
•    Tenormin increases the blood-pressure-lowering effects of
other blood-pressure-reducing agents, including clonidine,
guanabenz, and reserpine; and calcium channel blockers,such as nifedipine.
•    Aspirin-containing drugs, indomethacin, and sulfinpyrazone may interfere with the blood-pressure-lowering effect of atenoloi.
•    Cocaine may reduce the effectiveness of all beta blockers.
•    Tenormin may worsen the problem of cold hands and feet associated with taking ergot alkaloids, used to treat migraine. Gangrene is a possibility in people taking both           anergot and Tenormin.
•    Tenormin will counteract thyroid hormone replacements.
•    Calcium channel blockers, diphenhydramine, flecainide, hydralazine, contraceptive drugs, propafenone, haloperidol, phenothiazine sedatives—molindone and others—quinolone         antibacterials, and quinidine may increase the amount of Tenormin in the bloodstream and lead to increased Tenormin effects.
•    Tenormin should not be taken within 2 weeks of taking a monoamine oxidase inhibitor (MAGI) antidepressant.
•    Cimetidine increases the amount of Tenormin absorbed into the bloodstream from oral tablets.
•    Tenormin may interfere with the effectiveness of some anti-asthma drugs, including theophylline and aminophylline, and especially ephedrine and isoproterenol.
•    Combining Tenormin with phenytoin or digitalis drugs may result in excessive slowing of the heart, possibly causing heart block (disruption of the electrical impulses that       control heart rate).
•    If you stop smoking while taking Tenormin, your dose may have to be reduced because your liver will break down the drug more slowly.
•    Aluminum salts, barbiturates, calcium salts, cholestyramine, colestipol, ampicillin, and rifampin may reduce the effectiveness of Tenormin.
•    Beta blockers may increase the effects of gabapentin, lidocaine, or prazosin, leading to undesirable reactions or toxicity.
•    Beta blockers may block the effects of epinephrine.
•    Fluoxetine, paroxetine, bupropion, propafenone, quinidine, duloxetine, and terbinafine can substantially increase the amount of nebivolol in the blood by interfering with        its breakdown by liver enzymes. Amiodarone, cimetidine, and sertraline also have this interaction but the effect is smaller. Avoid these combinations.
•    Other drugs that can increase nebivolol levels but to a much smaller extent are antihistamines, celecoxib, chlorpheniramine, chlorpromazine, citalopram, clemastine,           clomipramine, diphenhydramine, doxepin, doxorubicin, escitalopram, halotantrine, histamine, hydroxyzine, levomepromazine, methadone, metoclopramide, mibefradil, midodrine,       moclobemide, perphenazine, ranitidine, haloperidol, ritonavir, ticlopidine, and tripelennamine.
•    Dexamethasone, rifampin, and sildenafil reduce blood levels of nebivolol but the combined effect on blood pressure is moderate.

Food Interactions

These drugs may be taken without regard to food or meals.

Usual Dose:

Tenormin

Adult: 50 mg a day. Some people may require doses of 100-200 mg a day. Dosages over 100 mg a day are not likely to produce additional benefit to those being treated for hypertension. People with kidney disease may need only 50 mg every other day. Older adults should be treated more cautiously and may need a lower dose.
Child: not recommended.

Overdosage

Symptoms of overdose include changes in heartbeat—unusually slow, unusually fast, or irregular—severe dizziness or fainting, breathing difficulties, bluish-colored fingernails or palms, and seizures. Heart failure and shock may also result from a beta blocker overdose. The victim should be taken to a hospital emergency room. ALWAYS bring the prescription bottle or container.

Special Information

These drugs are meant to be taken continuously.
When ending treatment, dosage should be reduced gradually over a period of about 2 weeks. Do not stop taking these drugs unless directed to do so by your doctor. Abrupt withdrawal may cause chest pain, breathing difficulties, increased sweating, and unusually fast or irregular heartbeat.
Call your doctor at once if you develop back or joint pain, breathing difficulties, cold hands or feet, depression, rash, or changes in heartbeat. Tenormin may produce an undesirable lowering of blood pressure, leading to dizziness or fainting; call your doctor if this happens. Call your doctor if you experience persistent or bothersome anxiety, diarrhea, constipation, impotence, headache, itching, nausea or vomiting, nightmares or vivid dreams, upset stomach, insomnia, stuffy nose, frequent urination, unusual tiredness, or weakness.
Tenormin may cause drowsiness, lightheadedness, dizziness, or blurred vision. Be careful when driving or performing complex tasks.
It is best to take beta blockers at the same time each day. If you forget a dose, take it as soon as you remember. If you take nebivolol and do not remember until your next dose, continue with your regular schedule. If you take Tenormin once a day and it is within 8 hours of your next dose, skip the dose you forgot and continue with your regular schedule. If you take Tenormin twice a day and it is within 4 hours of your next dose, skip the one you forgot and continue with your regular schedule. Never take a double dose of Tenormin or nebivolol.

Special Populations

Pregnancy/breast-feeding: Infants born to women who took a beta blocker while pregnant had lower birth weights, low blood pressure, and reduced heart rates. These drugs should be avoided by pregnant women and women who might become pregnant while taking them.
Tenormin and nebivolol pass into breast milk. Nursing mothers should use infant formula.
Seniors: Seniors taking Tenormin should use the lowest effective dose as this group is more likely to have decreased heart, kidney, and liver function, and to be taking additional medications. Dosage adjustment of nebivolol is not necessary in seniors.

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May

20

Acupuncture in Prostate Treatment

May 20, 2011 | Leave a Comment

ACUPUNCTURE

Acupuncture is an ancient Chinese therapy, some 3,500 years old. Its name is based on the Latin words acus, meaning needle, and punctus, meaning to prick or puncture what is the medicine atenolol . This becomes clear when you know that when patients have acupuncture, they are treated by having needles put into their skin.
Needles are put into the skin at particular points, known as acupuncture points, on the body. These lie along a network of invisible energy channels, called ‘meridians’. It is believed that the meridians are responsible for the flow of energy throughout the body and that they are linked to the body’s internal organs. Traditional Chinese medicine is based on the belief that good health is based on a perfect balance of the energy flowing through the body. Very fine stainless steel needles with very small heads are inserted into the acupuncture points, the idea being that they regulate the flow of energy, known as Qi, through the meridians. This may mean unblocking it, increasing it, or decreasing it. Some acupuncturists also apply local heat to supplement the body’s natural flow of energy. The most common way of doing this is moxibustion, which is done by placing moxa - the shredded leaves of the common mugwort - over the acupuncture point. It is then set alight and when it becomes too hot, it is removed. This may be repeated a number of times, and an acupuncture needle is then inserted as usual.

Does it work?

Acupuncture has been used in Britain since the early nineteenth century, primarily for the relief of pain and the treatment of fever, but also to stimulate the body’s own ability to heal itself. It used to be dismissed as nonsense by sceptics, but the fact that it has enormous success can no longer be denied. Acupuncturists claim success in relieving symptoms from prostate problems by using pressure points governing the bladder, large intestine, spleen and kidney. These are points on the lower abdomen and on the inner side of the lower leg.

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May

20

Baclofen

May 20, 2011 | Leave a Comment

Baclofen

Generic Name: Baclofen
Type of Drug: Skeletal muscle relaxant.

Prescribed For: Muscle spasms associated with multiple sclerosis (MS), spinal cord injury or disease, or other nervous system conditions; may also be used to treat trigeminal neuralgia (tic douloureux), hiccups, acid reflux, and as migraine prevention.

Baclofen may work by interfering with nervous system reflexes at the spinal cord, although it may also have some effect outside the spinal cord. Baclofen is chemically similar to a natural nerve transmitter known as GABA; baclofen’s effect on muscle spasm may be related to its effect on GABA nerve receptors.

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Cautions and Warnings

Do not take baclofen if you are allergic or sensitive to any of its ingredients. It should not be taken for muscle spasm resulting from rheumatic disease, stroke, cerebral palsy, or Parkinson’s disease because its benefit in these situations has not been proven. The condition of people with epilepsy or psychotic disorders may worsen while taking baclofen. About 4% of women with MS who take baclofen for less than 1 year develop ovarian cysts that usually disappear on their own. This is within the normal range for all women-1-5%—for developing ovarian cysts. Baclofen is excreted primarily through the kidneys, so patients with kidney disease or impaired kidney function should use baclofen with caution. Abruptly stopping baclofen can lead to hallucinations and seizure. Dosage should always be gradually reduced, except in cases of severe side effects.

Possible Side Effects of Baclofen

Baclofen may affect lab tests for liver function and can raise blood sugar levels.
Most common: drowsiness, low blood pressure, weakness, dizziness, lightheadedness, nausea and vomiting, headache, and sleeplessness.
Less common: frequent urination, fatigue or lethargy, confusion, euphoria, excitement, depression, hallucinations, tingling in the hands or feet, muscle pain, ringing or buzzing in the ears, coordination difficulties, tremors, rigidity, weakness, loss of muscle tone, unusual eye movement and other muscle-control problems, double vision, pinpoint or wide-open pupils, breathing difficulties, heart palpitations, dry mouth, appetite loss, changes in sense of taste, abdominal pain, diarrhea, bedwetting, difficulty urinating, painful urination, impotence, gash, Itching, swelling of the ankle, excessive sweating, weight gain, and stuffy MSe.
•    Rare: slurred speech, blurred vision, seizure, fainting, chest pain, blood in the urine, and testing positive for blood in the stool. Contact your doctor if you experience any side effect not listed above taking Baclofen.

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Baclofen Interactions

•    Avoid alcoholic beverages and other nervous system depressants such as antihistamines, sedatives, or narcotic pain relievers while taking baclofen.
•    Combining a monoamine oxidase inhibitor (MA01) antidepressant with baclofen may cause drowsiness, nervous system depression, and low blood pressure.
•    Combining a tricyclic antidepressant with baclofen may lead to severe muscle weakness.
•    Baclofen may increase blood sugar. Diabetics may need to increase their dosage of antidiabetic drugs to account for this effect.
•    Combining blood-pressure-lowering drugs with baclofen may lead to dizziness or fainting due to severe lowering of blood pressure.

Food Interactions

This drug may be taken without regard to food or meals.

Usual Dose

Adult and Child: Baclofen 5 mg 3 times a day for 3 days, gradually increased every 3 days until the desired effect is achieved, usually at Baclofen 40-80 mg a day. People with kidney disease require lower doses.

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Baclofen Overdosage

Symptoms of baclofen overdose include vomiting, loss of muscle tone, twitching, convulsions, pinpoint or wide-open pupils, drowsiness, blurred or double vision, breathing difficulties, seizure, and coma. Overdose victims should be taken to a hospital emergency room for treatment. ALWAYS bring the prescription bottle or container.

Special Information on Baclofen

Baclofen is a nervous system depressant. Take care when driving or doing anything that requires concentration and physical coordination.
Call your doctor if you develop persistent symptoms such as painful urination, constipation, nausea, headache, sleeplessness, or confusion.
Do not stop taking baclofen on your own. Abruptly stopping this drug may lead to hallucinations or seizure.
Your pharmacist may prepare a baclofen liquid. This mixture should be kept in the refrigerator and must be thrown away after I month.

If you forget a dose of baclofen and remember within 1 hour of your scheduled time, take it immediately. Do not take a double dose.

Special Populations

Pregnancy/Breast-feeding: Baclofen increases the chances of certain birth defects in lab animals. Pregnant women should only take baclofen after carefully weighing its possible benefits against its risks.

Baclofen taken by mouth passes into breast milk. Nursing mothers who must take this drug should use infant formula or receive the drug by injection directly into the spinal cord, because baclofen administered by injection does not pass into breast milk.
Seniors: Seniors may be more sensitive to nervous system side effects including hallucinations, depression, drowsiness, and confusion.

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